Abstract:
:Calcitonin gene-related peptide (CGRP) is expressed in and defines a subset of motor neuron pools in the lumbar spinal cord of the chick embryo. The onset of CGRP expression in individual pools coincides with both the period of the initial innervation of the leg and the beginning of naturally occurring cell death in the lumbar motor column. Administration of neuromuscular blocking agents at this time results in a striking reduction of normal motor neuron loss. It has been reported that such treatment also results in the abolition of CGRP expression at later stages of development. In this study, we have examined the effect of curare treatment on CGRP expression in motor neurons earlier in their development. We find that, in contrast to the effects reported at later stages, inhibition of neuromuscular activity does not affect either the onset of CGRP expression or its restriction to a subset of motor neuron pools. This demonstrates that the control of the onset of CGRP expression is unlikely to be linked to processes which are regulated by neuromuscular transmission including naturally-occurring cell death.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mason IJ,Mudge AWdoi
10.1016/0304-3940(92)90488-skeywords:
subject
Has Abstractpub_date
1992-04-13 00:00:00pages
128-32issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90488-Sjournal_volume
138pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2012-12-07 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2010-09-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2001-06-22 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2014-01-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11322-n
更新日期:1995-02-24 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2016-09-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.134705
更新日期:2020-01-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2018.12.007
更新日期:2019-02-16 00:00:00
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更新日期:2002-09-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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更新日期:1997-12-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2019-07-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1988-04-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12803-2
更新日期:1996-07-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(78)90114-3
更新日期:1978-01-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00618-9
更新日期:2003-09-18 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2002-04-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2000-11-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.06.090
更新日期:2009-09-22 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.07.014
更新日期:2016-08-26 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1998-06-12 00:00:00