Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells.

Abstract:

:An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate tumors. CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors. However, the biological function of CD133 protein remains unknown. In this study, we observed no significant effects on cell proliferation and migration in CD133 overexpressed U87MG human glioblastoma cells. It is reported that MAPK/Erk was constitutively activated in CD133 positive liver cancer stem cell. To find out possible mechanism between CD133 and Erk phosphorylation, we performed this study to evaluate the level of Erk phosphorylation in CD133 overexpressed U87MG cells. We found that CD133 overexpression significantly activated Erk, which suggested CD133 involved in activation of MAPK/Erk pathway.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Dong L,Qi N,Ge RM,Cao CL,Lan F,Shen L

doi

10.1016/j.neulet.2010.08.057

subject

Has Abstract

pub_date

2010-11-05 00:00:00

pages

210-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(10)01115-8

journal_volume

484

pub_type

杂志文章
  • Anxiety behavior is reduced, and physical growth is improved in the progeny of rat dams that consumed lipids from goat milk: an elevated plus maze analysis.

    abstract::The goat milk contains conjugated linoleic acid (CLA), which can influence physical growth and brain development. This study investigated the impact of a diet containing goat milk fat (GMF) on physical parameters of gestating (G) and/or lactating (L) rat dams, and their progeny's physical growth, and anxiety behavior....

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.07.028

    authors: Soares JK,de Melo AP,Medeiros MC,Queiroga RC,Bomfim MA,Santiago EC,Guedes RC

    更新日期:2013-09-27 00:00:00

  • Trigeminal projections to cerebellar tactile areas in the rat-origin mainly from n. interpolaris and n. principalis.

    abstract::Four new tactile areas in the cerebellar cortex (crus I, crus II, paramedian lobule and uvula) have recently been described in the rat. Ipsilateral orofacial regions are chiefly represented in these areas. Our study of trigeminocerebellar afferents to these areas using the HRP retrograde tracing technique shows that t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(78)90015-0

    authors: Watson CR,Switzer RC 3rd

    更新日期:1978-11-01 00:00:00

  • Respiratory function in mice lacking or overexpressing the prion protein.

    abstract::We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02536-8

    authors: Boudinot E,Tremblay P,Champagnat J,Foutz AS

    更新日期:2002-04-26 00:00:00

  • The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels.

    abstract::Evidence suggests that high peripheral beta-amyloid (Abeta)(1-40) levels and low ratios of Abeta(1-42)/Abeta(1-40) are associated with increased risk for Alzheimer's disease (AD). In this cross-sectional design, serum and plasma samples from 67 AD patients and 146 controls (similar in age and gender) were evaluated us...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.09.058

    authors: Abdullah L,Paris D,Luis C,Quadros A,Parrish J,Valdes L,Keegan AP,Mathura V,Crawford F,Mullan M

    更新日期:2007-11-27 00:00:00

  • Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.

    abstract::Acetaldehyde (AcH) and salsolinol play important roles in the central effects of ethanol. This study aimed to investigate the effect of administration of AcH on dopamine (DA), DA-derived salsolinol and serotonin (5-HT) levels in the dorsal striatum of Aldh2-knockout (Aldh2-KO) and C57BL/6 N (WT) mice. Animals were tre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.07.032

    authors: Ito A,Jamal M,Ameno K,Tanaka N,Takakura A,Kawamoto T,Kitagawa K,Nakayama K,Matsumoto A,Miki T,Kinoshita H

    更新日期:2018-10-15 00:00:00

  • Fast conducting electrosensory pathway in the mormyrid fish, Gnathonemus petersii.

    abstract::A compound action potential of short latency was recorded from the ganglion mesencephali extrolaterale in response to both the fish's own electric organ discharge and electric stimulation of the whole fish or a branch of the posterior lateral line nerve. The time difference between the response in the nerve, 16 mm fro...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(76)90004-5

    authors: Enger PS,Libouban S,Szabo T

    更新日期:1976-05-01 00:00:00

  • Influence of cholesterol depletion in plasma membrane of rat brain synaptosomes on calcium-dependent and calcium-independent exocytosis.

    abstract::It is well established that calcium-dependent neurotransmitter release and exocytosis can be regulated by altering the cholesterol content of the plasma membrane. We have compared the influence of cholesterol depletion of synaptosomal plasma membrane by 15 mM methyl-beta-cyclodextrin (MCD) treatment on calcium-depende...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.06.029

    authors: Waseem TV,Kolos VA,Lapatsina LP,Fedorovich SV

    更新日期:2006-09-11 00:00:00

  • Morphology of single afferents of the saccular macula in cats.

    abstract::The morphology of single saccular afferents was studied by the intracellular horseradish peroxidase (HRP) method. Four neurons were sufficiently stained to allow reconstruction of their axonal arborizations. The main axon of these neurons bifurcated into an ascending and a descending branch at the level of the lateral...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00944-0

    authors: Imagawa M,Graf W,Sato H,Suwa H,Isu N,Izumi R,Uchino Y

    更新日期:1998-01-16 00:00:00

  • Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

    abstract::Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.022

    authors: Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

    更新日期:2005-12-30 00:00:00

  • Characteristics of tooth pulp-driven neurons in the posterior group of the cat thalamus.

    abstract::This investigation was designed to determine the responses of neurons in the posterior group of nuclei (PO) to tooth pulp stimulation. Eighteen tooth pulp-driven (TPD) neurons were recorded in 9 cats anesthetized with nitrous oxide and halothane, 14 of them in the medial part (POM) and the remainder in the lateral par...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90091-2

    authors: Matsumoto N,Sato T,Sawano H,Tochinai A,Suzuki TA

    更新日期:1988-11-11 00:00:00

  • Short biotinylated oligonucleotides bind non-specifically to senile plaques of Alzheimer's disease.

    abstract::We have used in situ hybridization with biotinylated oligonucleotide (antisense) probes and streptavidin-biotinylated alkaline phosphatase method to detect the amount of amyloid beta-protein mRNA in the paraffin-embedded and formalin-fixed brain samples of patients affected by Alzheimer's disease and those of non-affe...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90234-k

    authors: Syrjänen S,Heinonen O,Miettinen R,Paljärvi L,Syrjänen K,Riekkinen P

    更新日期:1991-09-02 00:00:00

  • Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model.

    abstract::A prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depressed patients. Emerging studies n...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.12.046

    authors: Petersén A,Wörtwein G,Gruber SH,El-Khoury A,Mathé AA

    更新日期:2009-02-20 00:00:00

  • No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease.

    abstract::Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01330-6

    authors: Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

    更新日期:2000-08-25 00:00:00

  • Galanin and bethanechol appear to activate the same inwardly rectifying potassium current in mudpuppy parasympathetic neurons.

    abstract::Galanin- and bethanechol-activated whole cell currents were studied in dissociated mudpuppy parasympathetic neurons kept in 12.5 mM KCl. The bethanechol-induced current was reduced when generated during a galanin-induced current. The galanin and bethanechol currents reversed at -45 mV and exhibited inward rectificatio...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90675-w

    authors: Parsons RL,Merriam LA

    更新日期:1992-06-08 00:00:00

  • Antagonism of non-cholinergic excitatory junction potentials in the guinea-pig ileum by a substance P analogue antagonist.

    abstract::In the presence of atropine electrical transmural stimulation (using repetitive volleys, e.g. 3 pulses at 50 Hz applied every 4 s) of full thickness longitudinal strips of guinea-pig ileum produced non-cholinergic excitatory junction potentials (EJPs) and inhibitory junction potentials (IJPs) in the circular muscle la...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90006-6

    authors: Taylor GS,Bywater RA

    更新日期:1986-01-02 00:00:00

  • Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.

    abstract::Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2016.09.007

    authors: Wen X,Westergard T,Pasinelli P,Trotti D

    更新日期:2017-01-01 00:00:00

  • Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition.

    abstract::We reported here the functional characteristics of Na+ -dependent neutral amino acid transport system A in normal human astrocytes and its adaptive regulation, a process in which amino acid starvation induces the transport activity. Reverse transcription-PCR revealed that the system A transporter subtype, SNAT2/ATA2, ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.12.030

    authors: Tanaka K,Yamamoto A,Fujita T

    更新日期:2005-04-18 00:00:00

  • APOE genotypes in African American female multiple sclerosis patients.

    abstract::Multiple sclerosis (MS) is a chronic inflammatory CNS disorder, resulting in progressive neurological dysfunction. The disease has a higher incidence in Caucasian Americans (CA) than African Americans (AA); however, the latter may have a more aggressive disease course. We used cluster analysis to determine whether the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.12.049

    authors: Huang R,Hughes M,Mobley S,Lanham I,Poduslo SE

    更新日期:2007-02-27 00:00:00

  • A pre-positron emission tomography study of L-3,4-dihydroxy-[3H]phenylalanine distribution in the rat.

    abstract::The distribution of L-3,4-dihydroxy-[3H]phenylalanine (L-[3H]DOPA) was examined in rats following i.v. injection, to ascertain the possible usefulness of using this ligand to image dopaminergic systems using positron emission tomography. It was found that L-DOPA and its metabolites were preferentially localized in the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90179-x

    authors: Liskowsky DR,Potter LT

    更新日期:1985-01-21 00:00:00

  • Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese.

    abstract::Growing amounts of evidence suggest that N-Methyl-d-aspartate (NMDA) receptor mediated glutamate neurotransmission may be involved in the pathophysiology of drug dependence. The NMDA receptor consists of three subfamilies (NR1, NR2, and NR3). The ability of subunit NR3 to negatively modulate the NMDA receptor function...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.08.025

    authors: Xie X,Liu H,Zhang J,Chen W,Zhuang D,Duan S,Zhou W

    更新日期:2016-09-19 00:00:00

  • Persistent pain inhibits contralateral somatosensory cortical activity in humans.

    abstract::To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90088-o

    authors: Apkarian AV,Stea RA,Manglos SH,Szeverenyi NM,King RB,Thomas FD

    更新日期:1992-06-22 00:00:00

  • Whole-cell patch-clamp recordings from respiratory neurons in neonatal rat brainstem in vitro.

    abstract::Whole-cell recordings were obtained from respiratory neurons by applying patch-clamp techniques in the en bloc medulla of in vitro neonatal rat brainstem-spinal cord preparations. Stable voltage-clamp recordings of excitatory or inhibitory synaptic drive currents and current-clamp recordings of spike discharge of insp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90504-z

    authors: Smith JC,Ballanyi K,Richter DW

    更新日期:1992-01-06 00:00:00

  • Re-innervation of rat molar tooth pulp following transection of the inferior alveolar nerve.

    abstract::The inferior alveolar nerves (IAN) of young male Wistar rats (b.wt. greater than or equal to 200 g) were transected unilaterally, slightly proximal to the mandibular foramen under anesthesia with chloral hydrate (0.4 g/kg, i.p.). After various postoperative periods of time, the animals received horseradish peroxidase ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90707-g

    authors: Takemura M,Sugimoto T,Wakisaka S,Akai M

    更新日期:1990-01-01 00:00:00

  • N400 as an index of uncontrolled categorization processing in brand extension.

    abstract::This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.07.043

    authors: Wang X,Ma Q,Wang C

    更新日期:2012-09-06 00:00:00

  • WITHDRAWN: Analysis of Infection Factors after Radical Mastectomy for Breast Cancer by CT Image and AUTO-plan Intelligent Analysis under Regional Nerve Block.

    abstract::This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

    journal_title:Neuroscience letters

    pub_type: 撤回出版物

    doi:10.1016/j.neulet.2020.135214

    authors: Luo J,Wang Y,Li W,Long L,Cao H

    更新日期:2020-06-29 00:00:00

  • Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca(2+)-dependent mechanisms.

    abstract::Bisphenol-A (BPA), a toxic chemical from polycarbonate plastics, is known for behavioural and neural abnormalities. These neuro-behavioural changes reflect the changes in neural activity. However the effect of BPA on nerve action potential is not available. Therefore, present investigation was undertaken to study the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.04.044

    authors: Pandey AK,Deshpande SB

    更新日期:2012-05-31 00:00:00

  • Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains.

    abstract::Using immunohistochemistry, Fas and caspase 8 positive sites were localized in the brains of Alzheimer patients and those with multiple infarcts as well as age-matched normal. The frontal, occipital and hippocampal regions were dissected out from these patients and normal individuals shortly after death. Positive Fas ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.05.091

    authors: Yew DT,Ping Li W,Liu WK

    更新日期:2004-08-26 00:00:00

  • Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans.

    abstract::The contribution of the circadian pacemaker and the sleep homeostat to sleep tendency and consolidation was quantified by forced desynchrony of the sleep-wake cycle from the circadian pacemaker in eight men who lived in time-isolation for 33-36 days. Analysis of 175 polygraphically recorded sleep episodes revealed tha...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90841-9

    authors: Dijk DJ,Czeisler CA

    更新日期:1994-01-17 00:00:00

  • The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 reduces the expression of neuronal nitric oxide synthase in the hippocampus but not in the cerebral cortex and medial septal nucleus of rat.

    abstract::The expression of neuronal type of nitric oxide synthase (nNOS) has been studied by immunocytochemistry in the brain of rats receiving a single daily (for up to 14 consecutive days) intracerebroventricular (i.c.v.) injection of the HIV-1 recombinant protein gp 120 (100 ng/day). This treatment failed to affect nNOS exp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)13463-2

    authors: Bagetta G,Corasaniti MT,Costa N,Berliocchi L,Finazzi-Agrò A,Nisticò G

    更新日期:1997-03-14 00:00:00

  • 1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes.

    abstract::Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (N...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90213-q

    authors: Schoepp DD,True RA

    更新日期:1992-09-28 00:00:00