Abstract:
:Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on adenosine triphosphate (ATP) synthesis was studied using isolated mitochondrial preparations from mouse brains. Oxidation of glutamate + malate in the mitochondria estimated by polarography was significantly inhibited by MPP+, and synthesis of ATP was inhibited to approximately 9% of that of control by 0.06 mM of MPP+. Oxidation of alpha-glycerophosphate and succinate was not inhibited, and ATP was synthesized normally. Energy crisis appears to be one of the most important mechanisms of neuronal degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental parkinsonism.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mizuno Y,Suzuki K,Sone N,Saitoh Tdoi
10.1016/0304-3940(87)90366-1subject
Has Abstractpub_date
1987-10-16 00:00:00pages
204-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90366-1journal_volume
81pub_type
杂志文章abstract::Regular physical activity benefits brain health and function. Physical activity performed by young adults is declining. However, the influence of diminished physical activity on cognitive performance and motor preparation in young adults remains unclear. This study measured changes in behavior and brain activity durin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.12.045
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abstract::Transmeatal cochlear laser (TCL) treatment has recently been proposed as a therapeutic procedure for cochlear dysfunction such as chronic cochlear tinnitus or sensorineural hearing loss. The aim of this study was to investigate whether TLC has any influence on the central nervous system using functional MRI with healt...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2007-01-16 00:00:00
abstract::Numerous studies have provided evidence for a genetic association of the Apolipoprotein E (ApoE) epsilon4 allele and late onset familial and sporadic Alzheimer's disease (AD). Clinical observations show that a proportion of schizophrenic patients may suffer from severe cognitive impairment. That could reflect a partic...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1998-03-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90014-0
更新日期:1987-01-14 00:00:00
abstract::The effect of aconitine, a plant alkaloid known to bind at site 2 of the sodium channel, was investigated on neuronal excitability in hippocampal slices of adult and juvenile rats. Aconitine (0.01-1 microM) diminished the extracellularly recorded population spike in a concentration-dependent manner. At each concentrat...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12989-x
更新日期:1996-09-20 00:00:00
abstract::Pyramidal neurons in the mammalian cerebral cortex can be described by a fractal dimension (Mandelbrot, 1982), which is an objective, quantitative measure of the complexity of their soma/dendritic borders. In the cat, the fractal dimensions of lamina V cells, which include pyramidal tract neurons (PTN), indicate that ...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1991-09-02 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2017-08-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.08.072
更新日期:2012-10-31 00:00:00
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journal_title:Neuroscience letters
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更新日期:2003-03-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2009-10-25 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11342-8
更新日期:1995-03-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90038-1
更新日期:1983-07-29 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.05.020
更新日期:2008-07-11 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00427-9
更新日期:1999-07-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.06.050
更新日期:2016-08-26 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.07.026
更新日期:2013-09-27 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2003-01-30 00:00:00
abstract::To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5...
journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.03.076
更新日期:2008-05-30 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2007-05-07 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00085-8
更新日期:1998-02-27 00:00:00
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journal_title:Neuroscience letters
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更新日期:2004-08-05 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2004-09-23 00:00:00
abstract::The conversion of α-synuclein from its natively unfolded and α-helical tetrameric forms to an amyloid conformation is central to the emergence of Parkinson's disease. Therefore, prevention of this conversion may offer an effective way of avoiding the onset of this disease or delaying its progress. At different concent...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2017-03-22 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.10.077
更新日期:2011-01-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1992-08-31 00:00:00