Abstract:
:The effects of intracerebroventricular (i.c.v.) administration of dopamine receptor antagonists on the calcium-dependent brain function that reduces blood pressure were investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) was reduced following i.c.v. administration of calcium chloride (100 microg/rat), and this effect of calcium chloride was attenuated by i.c.v. injection of eticlopride (dopamine D2 receptor antagonist, 100 microg/rat), but not by i.c.v. injection of SCH 23390 (dopamine D1 receptor antagonist, 30 microg/rat). Taking into consideration these results with our previous reports, it is suggested that calcium enhances dopamine synthesis in the brain through a calmodulin-dependent system, and that the resultant increase in dopamine levels inhibits sympathetic activity via the dopamine D2 receptor in the brain and reduces the blood pressure in SHR.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sutoo D,Akiyama Kdoi
10.1016/s0304-3940(99)00427-9keywords:
subject
Has Abstractpub_date
1999-07-16 00:00:00pages
133-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394099004279journal_volume
269pub_type
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