Abstract:
:The mechanism underlying the over-recovery of an M-type potassium current following the washout of muscarine (20 microM) has been examined. Whole-cell recordings were made from single neurons dissociated from bullfrog sympathetic ganglia. During over-recovery, the maximum M-conductance decreased by about 2.8 nS while the steady-state M-current activation curve was displaced in the hyperpolarizing direction by about 13 mV. These data suggest that a hyperpolarizing shift in the kinetics of M-current causes over-recovery in amphibian autonomic neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tokimasa T,Simmons MA,Schneider CR,Akasu Tdoi
10.1016/0304-3940(96)12495-2subject
Has Abstractpub_date
1996-03-29 00:00:00pages
97-100issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(96)12495-2journal_volume
207pub_type
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