Abstract：
:The coupling of muscarinic agonist receptors to guanine nucleotide-binding (G) proteins was investigated in the frontal, temporal cortices and thalamus of control and Alzheimer brains by using carbachol in competition experiments with [3H]QNB. In the presence of GppNHp, the carbachol/[3H]QNB competition binding data showed a 6-fold increase in the high-affinity muscarinic agonist coefficient (Ki high) in the thalami of control brains and a significantly increased proportion of low-affinity agonist binding sites (Bmax low) in the temporal cortices of control brains, while no significant effect of GppNHp was observed in Alzheimer brains. The results suggest a disturbance of the muscarinic receptor-G protein coupling in Alzheimer's disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Warpman U,Alafuzoff I,Nordberg Adoi
10.1016/0304-3940(93)90103-rsubject
Has Abstractpub_date
1993-02-05 00:00:00pages
39-43issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90103-Rjournal_volume
150pub_type
杂志文章abstract：:The possibility that single electrical shock stimulation of somatic afferent nerves could evoke a reflex response in vagal efferent nerves innervating the stomach was examined using anesthetized, artificially-ventilated rats. A single shock to a hindlimb afferent nerve (tibial nerve) produced two distinct reflex compo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12660-4
更新日期：1996-05-24 00:00:00
abstract：:Indirect Wallerian degeneration after sectioning the infraorbital nerve, and retrograde axonal transport following injection of horseradish peroxidase (HRP) into the maxillary nerve were studied in rats. These experiments showed the existence of primary trigeminal neurons in the pars caudalis of the ipsilateral trigem...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90333-x
更新日期：1980-02-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12808-1
更新日期：1996-07-12 00:00:00
abstract：:The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.11.007
更新日期：2006-03-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90824-s
更新日期：1990-11-13 00:00:00
abstract：:In this review, we summarize the recent development of positron emission tomography (PET) radioligands for γ-aminobutyric acid A (GABAA) receptors and their potential to measure changes in endogenous GABA levels and highlight the clinical and translational applications of GABA-sensitive PET radioligands. We review the...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：2019-01-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-05-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.10.018
更新日期：2012-12-07 00:00:00
abstract：:The effect of oleamide on apoptosis was investigated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay, DNA staining assay with propidium iodide and caspase-3 activity analyses. The present results showed that oleamide significantly attenuated the cell death and nuclear condensation...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00460-3
更新日期：2002-08-09 00:00:00
abstract：:The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na+ influx, voltage-sensitive Na+ channels, in the AD induced by O2 and/or glucose deprivation. We recorded extracellular Na+ concentra...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00728-4
更新日期：1999-11-05 00:00:00
abstract：:The paraoxonase (PON1) Gln192-->Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1*R allele frequency significantly lower than the control group (0.225 vs. 0.281, P=...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-03-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90422-2
更新日期：1986-08-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.12.009
更新日期：2011-02-11 00:00:00
abstract：:Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail-withdrawal reflex in Aplysia is produced by sensitizing stimuli. These effects can be mimicked by perfusing the pleural and pedal ganglia of a semi-intact preparation with serotonin (5-HT). In addition to the synaptic fac...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90342-2
更新日期：1984-11-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.03.064
更新日期：2012-05-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90060-7
更新日期：1991-11-25 00:00:00
abstract：:Walking with different types of cueing/stimulus (i.e. auditory, visual) has been shown to alter gait variability, thus emerging as an innovative therapeutical tool to restore abnormal gait variability in clinical populations. However, the majority of the research in this area has focused on auditory stimuli while visu...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.03.040
更新日期：2019-06-21 00:00:00
abstract：:Plasma renin activity (PRA) was determined in plasma samples obtained approximately at 6-min intervals during consecutive non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) periods in rats chronically implanted with EEG electrodes, a brain thermistor, and an intracardiac catheter. PRA was low in ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90940-7
更新日期：1994-09-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.06.061
更新日期：2004-09-16 00:00:00
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journal_title：Neuroscience letters
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更新日期：2011-03-17 00:00:00
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journal_title：Neuroscience letters
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更新日期：2004-03-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.08.022
更新日期：2008-10-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.neulet.2004.03.084
更新日期：2004-07-01 00:00:00
abstract：:Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in clinical trials. We and others have shown that inhibi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.10.038
更新日期：2019-01-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)13081-0
更新日期：1996-10-25 00:00:00
abstract：:The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol i...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01466-x
更新日期：2000-10-27 00:00:00
abstract：:Acetylcholine, synthesized in the cytoplasm of cholinergic neurons by choline acetyltransferase (ChAT), is packaged in synaptic vesicles by vesicular acetylcholine transporter (VAChT). The entire VAChT gene has been reported to be located within the first intron of the ChAT gene. In order to examine whether or not ChA...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00763-5
更新日期：1997-10-31 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90377-4
更新日期：1983-08-08 00:00:00
abstract：:2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and can...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.11.007
更新日期：2009-01-16 00:00:00
abstract：:The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C rec...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90032-3
更新日期：1989-10-23 00:00:00
