Abstract:
:The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the effect of clock perturbation by exogenous melatonin injection on two hormonal clock outputs: pineal melatonin and adrenal corticosterone secretions. As already reported, a single melatonin injection at the light/dark transition induces a marked increase in the endogenous pineal melatonin peak for the two following days. In the same animals, by contrast, the amplitude of the corticosterone rhythm was not altered following melatonin injection. These data show that the melatonin injection does not display an overall effect on the circadian clock, but rather influences a subpopulation of melatonin-sensitive neurons involved, among other functions, in the circadian control of the pineal pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tritschler L,Saboureau M,Pévet P,Bothorel Bdoi
10.1016/j.neulet.2005.11.007keywords:
subject
Has Abstractpub_date
2006-03-20 00:00:00pages
73-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(05)01287-5journal_volume
396pub_type
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