Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices.

Abstract:

:Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7.9 microM). KYNA is produced endogenously by transamination of its precursor L-kynurenine (L-KYN). We tested the hypothesis that effects of endogenous, de novo produced KYNA, following bath-application of L-KYN to slices, would be different than effects of commercially-synthesized (exogenous) KYNA. The ability to block spontaneous epileptiform activity, induced by lowering extracellular magnesium, was examined in area CA3 of hippocampus and the entorhinal cortex. At a concentration of 200 microM L-KYN, which produced 0.89 +/- 0.20 microM KYNA, there were fewer slices with spontaneous epileptiform activity than slices exposed to 2 microM exogenous KYNA. The results indicate a more potent neuromodulatory action of endogenous KYNA than has been previously realized.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Scharfman HE,Hodgkins PS,Lee SC,Schwarcz R

doi

10.1016/s0304-3940(99)00690-4

keywords:

subject

Has Abstract

pub_date

1999-10-22 00:00:00

pages

111-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00690-4

journal_volume

274

pub_type

杂志文章
  • Delayed visual feedback reveals distinct time scales in balance control.

    abstract::We performed an experiment in which we challenged postural stability in 12 healthy subjects by providing artificial delayed visual feedback. A monitor at eye-height presented subjects with a visual representation of the location of their center-of-pressure (COP) and they were instructed to position their COP as accura...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.01.024

    authors: van den Heuvel MR,Balasubramaniam R,Daffertshofer A,Longtin A,Beek PJ

    更新日期:2009-03-06 00:00:00

  • Evaluation of age-related plantar-surface insensitivity and onset age of advanced insensitivity in older adults using vibratory and touch sensation tests.

    abstract::Age-related decline in plantar-surface sensitivity has been cited as one of the reasons for balance problems in older adults. This study investigated the level of plantar-surface sensitivity in older adults compared to young adults. Additionally, this study attempted to identify the onset age of advanced insensitivity...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.060

    authors: Perry SD

    更新日期:2006-01-09 00:00:00

  • Sexual dimorphism in song-induced ZENK expression in the medial striatum of juvenile zebra finches.

    abstract::In the brains of male zebra finches (Taeniopygia guttata), the nuclei that direct song learning and production are larger than the corresponding regions in females, who do not sing. The dimorphism in Area X of the medial striatum (MSt), an area important for song learning, is even more dramatic in that it is identifia...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.02.076

    authors: Bailey DJ,Wade J

    更新日期:2006-06-19 00:00:00

  • The effect of operant-conditioning balance training on the down-regulation of spinal H-reflexes in a spastic patient.

    abstract::Spasticity in chronic hemiparetic stroke patients has primarily been treated pharmacologically. However, there is increasing evidence that physical rehabilitation can help manage hyper-excitability of reflexes (hyperreflexia), which is a primary contributor to spasticity. In the present study, one chronic hemiparetic ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.09.009

    authors: Hoseini N,Koceja DM,Riley ZA

    更新日期:2011-10-24 00:00:00

  • Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis.

    abstract::During hyperalgesia there is an enhancement of wind-up and the appearance of a novel wind-up of the A-fibre-mediated responses. We have examined if these phenomena are influenced by supraspinal mechanisms by analysing single motor unit activity in control and arthritic rats, either intact or acutely spinalised. Enhanc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12588-x

    authors: Herrero JF,Cervero F

    更新日期:1996-05-03 00:00:00

  • The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice.

    abstract::Increasing evidence shows that inflammation may contribute to the pathophysiology of depression. Apigenin, one type of natural flavone, has a number of biological actions including anti-inflammatory effects. Although it has potential antidepressant activity in a chronic mild stress model, the mechanisms of antidepress...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.03.040

    authors: Li R,Zhao D,Qu R,Fu Q,Ma S

    更新日期:2015-05-06 00:00:00

  • Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

    abstract::Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.022

    authors: Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

    更新日期:2005-12-30 00:00:00

  • Activation of opioid mu-receptor by sinomenine in cell and mice.

    abstract::Sinomenine, one of the alkaloids extracted from roots or stems of Sinomenium acutum, is documented to show antinociceptive action but the action mechanism is still unclear. The present study was aimed to investigate the effect of sinomenine on opioid mu-receptor (OMR). In Chinese Hamster Ovary (CHO) cell transfected w...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.07.088

    authors: Wang MH,Chang CK,Cheng JH,Wu HT,Li YX,Cheng JT

    更新日期:2008-10-10 00:00:00

  • No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease.

    abstract::Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropat...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3940(02)00098-8

    authors: Fidani L,Compton D,Hardy J,Petersen RC,Tangalos E,Mirtsou V,Goulas A,De Vrieze FW

    更新日期:2002-04-12 00:00:00

  • Loss of short-latency afferent inhibition and emergence of afferent facilitation following neuromuscular electrical stimulation.

    abstract::Neuromuscular electrical stimulation (NMES) increases the excitability of corticospinal (CS) pathways by altering circuits in motor cortex (M1). How NMES affects circuits interposed between the ascending afferent volley and descending CS pathways is not known. Presently, we hypothesized that short-latency afferent inh...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.08.072

    authors: Mang CS,Bergquist AJ,Roshko SM,Collins DF

    更新日期:2012-10-31 00:00:00

  • Effects of ascorbate in microdialysis perfusion medium on the extracellular basal concentration of glutamate in rat's striatum.

    abstract::There are many evidences suggest that ascorbate in the extracellular space can affect glutamate concentration in the rat's brain. In this report, we studied how ascorbate in microdialysis perfusion medium affected glutamate level at the striatum in freely-moving rats. Three perfusion mediums were used: 0, 250, and 400...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00966-0

    authors: Lai YJ,Shen EY,Pan WH

    更新日期:2000-02-04 00:00:00

  • Interaction of pentobarbital with gabaergic drugs acting on the Cl(-)-ATPase activity of the plasma membranes from bream brain (Abramis brama L.).

    abstract::The present study was designed to investigate the role of the interaction of pentobarbital with gamma-aminobutyric acid (GABA)ergic drugs acting on the Cl(-)-adenosine triphosphate (ATP)ase activity of the plasma membranes fraction of bream brain. The preincubation and then incubation of the membranes with pentobarbit...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)01076-5

    authors: Menzikov S,Menzikova O

    更新日期:2002-12-16 00:00:00

  • The basal nucleus of Meynert in patients with progressive supranuclear palsy.

    abstract::The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrate...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90217-9

    authors: Tagliavini F,Pilleri G,Bouras C,Constantinidis J

    更新日期:1984-01-27 00:00:00

  • Injection of a cholinergic agonist in the dorsolateral pontine tegmentum of cats affects the posturokinetic responses to cortical stimulation.

    abstract::Microinjection into the dorsolateral pontine tegmentum of the muscarinic agonist bethanechol, leading to activation of cholinoceptive pontine reticular formation (pRF) neurons and the related medullary inhibitory reticulospinal system, did not modify the threshold, latency and amplitude of the forelimb flexion elicite...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90431-8

    authors: Luccarini P,Gahery Y,Pompeiano O

    更新日期:1990-06-22 00:00:00

  • Cued and spatial learning in the water maze: equivalent learning in male and female mice.

    abstract::Mammals navigate a complex environment using a variety of strategies, which can operate in parallel and even compete with one another. We have recently described a variant water maze task in which two of these strategies, hippocampus-dependent spatial learning and striatum-dependent cued learning, can be dissociated. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.07.082

    authors: Baldan Ramsey LC,Pittenger C

    更新日期:2010-10-11 00:00:00

  • 1-Oleoyl-2-docosahexaenoyl phosphatidylcholine increased paradoxical sleep in F344 rats.

    abstract::The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 micrograms/rat induced significant increase in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90604-j

    authors: Hashimoto M,Gong XW,Izaki Y,Iriki M,Hibino H

    更新日期:1993-08-06 00:00:00

  • Type-specific expression of protein kinase C isozymes in CNS tumor cells.

    abstract::We examined specific expression of protein kinase C (PK-C) isozymes in cultured human glial and neuronal cell lines, using type-specific monoclonal antibodies MC-1a, -2a, and -3a (Hidaka H. et al., J. Biol. Chem., 263 (1988) 4523-4526). Immunoblotting experiments revealed that a 80 kDa band of three kinds of glioblast...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90698-9

    authors: Shimosawa S,Hachiya T,Hagiwara M,Usuda N,Sugita K,Hidaka H

    更新日期:1990-01-01 00:00:00

  • Protective effects of dopamine D2/D3 receptor agonist piribedil on learning and memory of rats exposed to global cerebral ischemia-reperfusion.

    abstract::Global cerebral ischemia-reperfusion (GCI/R) may occur after any of several clinical conditions such as cardiac arrest and anesthetic accident. Some dopamine receptor agonists possess neuroprotective effects. However, some of them may produce side effects during treatment. Piribedil, which is a dopamine D2/D3 receptor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.08.011

    authors: Wang W,Liu L,Chen C,Jiang P,Zhang T

    更新日期:2018-09-25 00:00:00

  • Proton-induced Na+ current develops prior to voltage-dependent Na+ and Ca2+ currents in neuronal precursor cells from chick dorsal root ganglion.

    abstract::Proton-induced Na+ currents (INa(H] were measured in precursor cells from chick dorsal root ganglia with whole-cell patch-clamp recording. Precursor cells were isolated using the method of Rohrer et al. (EMBO. J., 4 (1985) 1709-1714) and fast pH changes were applied with a technique developed by Davies et al. (J. Phys...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90270-x

    authors: Gottmann K,Dietzel ID,Lux HD,Ruedel C

    更新日期:1989-04-24 00:00:00

  • Neuroglobin protects against nitric oxide toxicity.

    abstract::Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.10.031

    authors: Jin K,Mao XO,Xie L,Khan AA,Greenberg DA

    更新日期:2008-01-10 00:00:00

  • Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex.

    abstract::We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glyco...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.020

    authors: Kang UG,Jeon WJ,Kim Y,Chung CK,Park JB,Juhnn YS,Kim YS

    更新日期:2005-12-30 00:00:00

  • Proteasome regulates transcription-favoring histone methylation, acetylation and ubiquitination in long-term synaptic plasticity.

    abstract::Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.02.029

    authors: Bach SV,Tacon PR,Morgan JW,Hegde AN

    更新日期:2015-03-30 00:00:00

  • Nucleotide signaling in astrogliosis.

    abstract::Acute and chronic damage to the central nervous system (CNS) releases large quantities of ATP. Whereas the ATP concentration in the extracellular space is normally in the micromolar range, under these conditions it increases to millimolar levels. A number of ligand-gated cationic channels termed P2X receptors (7 mamma...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2013.09.056

    authors: Franke H,Illes P

    更新日期:2014-04-17 00:00:00

  • Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E.

    abstract::Recent evidence indicates that alterations in brain polyamine metabolism may be critical for nerve cell survival after a free radical initiated neurodegenerative process. It has been shown previously that A beta(1-42) and A beta(25-35) are toxic to neurons through a free radical dependent oxidative mechanism. Treatmen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00101-9

    authors: Yatin SM,Yatin M,Aulick T,Ain KB,Butterfield DA

    更新日期:1999-03-19 00:00:00

  • Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.

    abstract::Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2016.09.007

    authors: Wen X,Westergard T,Pasinelli P,Trotti D

    更新日期:2017-01-01 00:00:00

  • Down regulation of TRPC1 by shRNA reduces mechanosensitivity in mouse dorsal root ganglion neurons in vitro.

    abstract::Mechanosensitivity is a crucial but poorly understood property of the sensory nervous system. Transient receptor potential (TRP) channels, which have been found to be responsible for the detection of other sensory stimuli such as temperature and pungent chemicals, have been suggested to also recognize stretch or press...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.03.082

    authors: Staaf S,Maxvall I,Lind U,Husmark J,Mattsson JP,Ernfors P,Pierrou S

    更新日期:2009-06-19 00:00:00

  • Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart.

    abstract::This is the first report of the presence of nitric oxide synthase (NOS) immunoreactivity and NADPH-diaphorase (NADPH-d) activity in a subpopulation of the intrinsic neurones that innervate the heart. A cytochemical technique to detect NADPH-d and antisera raised against purified rat cerebellar NOS were employed to exa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90234-x

    authors: Hassall CJ,Saffrey MJ,Belai A,Hoyle CH,Moules EW,Moss J,Schmidt HH,Murad F,Förstermann U,Burnstock G

    更新日期:1992-08-31 00:00:00

  • Effect of different frequencies of music on blood pressure regulation in spontaneously hypertensive rats.

    abstract::The effect of different frequencies of music on brain function was investigated through measurement of blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that exposure to Mozart's music (K. 205) leads to increased calcium/calmodulin-dependent dopamine synthesis in the brain, and that t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.09.073

    authors: Akiyama K,Sutoo D

    更新日期:2011-01-03 00:00:00

  • Evidence against an exclusive role of glutamate in kainic acid neurotoxicity.

    abstract::Transection of the non-glutamatergic septohippocampal fibers 3-5 days prior to intrahippocampal microinjection of 1 microgram kainic acid (KA) or 3 micrograms ibotenic acid (IBO) protect dentate granule cells against KA but not IBO. In the transected animals, a significant reduction of KA-induced behavioral seizures c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90268-2

    authors: Schwarcz R,Köhler C

    更新日期:1980-10-02 00:00:00

  • Cell that are O4 antigen-positive and O1 antigen-negative differentiate into O1 antigen-positive oligodendrocytes.

    abstract::In freshly dissociated viable cells of early postnatal mouse cerebellum, O1 antigen-positive oligodendrocytes have been eliminated by complement dependent immunocytolysis. Before seeding residual cells in culture, O4 antigen-positive cells were immunolabeled by O4 antibody which had been directly conjugated with rhoda...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(82)90351-2

    authors: Sommer I,Schachner M

    更新日期:1982-04-16 00:00:00