Abstract:
:The function of acetylcholine (ACh) in the mammalian pineal gland is unknown. To test the hypothesis that ACh exerts a modulatory role in this organ, in the present study electrophysiogical multiunit recordings were carried out in ex-vivo rat pineal glands superfused with different drugs. It was found that ACh (10(-7) M) as well as the cholinergic agonists oxotremorine (10(-7) M) and nicotine (10(-6) M) increased the discharge rates of most of the spontaneously active units and led to burst activity in previously regularly firing cells. It is concluded that ACh may play a modulatory role in the pineal by influencing the firing of a special population of pineal cells with perhaps receptor function.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schenda J,Vollrath Ldoi
10.1016/s0304-3940(98)00624-7subject
Has Abstractpub_date
1998-09-18 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00624-7journal_volume
254pub_type
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