Abstract：
:The brains of 7 dogs aged 6 to 18 years have been histochemically and immunohistochemically investigated at the light- and electron microscopy levels for preamyloid deposits and amyloid fibrils to verify the hypothesis that the accumulation of cleavage products of amyloid precursor protein is related not only to Alzheimer's disease but also to the normal aging of the brain. Preamyloid deposits were detected in the neuropil of the cerebral cortex and neostriatum, whereas amyloid fibrils were found in the walls of parenchimal and leptomeningeal vessels. The densities of preamyloid deposits in the neuropil and of deposits of amyloid fibrils in the vessel walls were higher in the brains of the most aged dogs. These findings suggest that aging of the canine brain is characterized by an accumulation of intermediate cleavage products of the amyloid precursor protein in both the neuropil and the vessel walls, and by processing of these products to amyloid fibrils in the vessel walls.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Giaccone G,Verga L,Finazzi M,Pollo B,Tagliavini F,Frangione B,Bugiani Odoi
10.1016/0304-3940(90)90068-ksubject
Has Abstractpub_date
1990-07-03 00:00:00pages
178-83issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90068-Kjournal_volume
114pub_type
杂志文章abstract：:The transcription factors AP-2alpha and AP-2beta are implicated to play an important role during embryonic development of different parts of the brain, and in targeted regulation of gene expression in the adult brain. Several monoaminergic genes have binding sites for AP-2 in regulatory regions. We have in the present...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2013-02-08 00:00:00
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1999-09-10 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2008-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1990-03-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1994-10-24 00:00:00
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pub_type： 杂志文章
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更新日期：1997-09-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90164-5
更新日期：1990-11-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-12-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(76)90056-2
更新日期：1976-12-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-08-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1996-04-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01746-3
更新日期：2001-05-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.01.046
更新日期：2018-04-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-08-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1996-10-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2016-10-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90701-3
更新日期：1994-01-03 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12641-0
更新日期：1996-06-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.09.025
更新日期：2017-11-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00497-8
更新日期：1999-09-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
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更新日期：2002-04-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.06.002
更新日期：2007-07-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90642-4
更新日期：1994-04-25 00:00:00
abstract：:The effects of a series of chloride transport blockers (ethacrynate, furosemide, torasemide, 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene and diphenylcarboxylate) on Cl(-)-dependent L-[3H]glutamate (Glu) binding were tested in rat brain membranes, Cl-transport blockers inhibit the Ca2+/Cl(-)-induced increase in L...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90151-0
更新日期：1987-02-24 00:00:00
