Abstract:
:The effect of preconditioning (PC) on the changes of nerve growth factor-induced gene A (NGFI-A) expression induced by severe hypobaric hypoxia was studied by in situ hybridization. A PC consisted of three trials of mild hypobaric hypoxia (360 Torr, 2 h) spaced at 24 h. The last trial was followed by severe hypoxia (SH; 180 Torr, 3 h) 24 h later. The PC hypoxia prevented the NGFI-A messenger RNA (mRNA) increase in the cortex, neostriatum, piriform cortex, amygdala and hippocampus detected 3 h after SH. The preconditioned SH caused a peak in NGFI-A mRNA expression at the 24 h time-point and thus abolished the dramatic decrease of the mRNA in vulnerable areas seen by 24 and 72 h after SH. The findings suggest a role of brain NGFI-A in the protective effect of hypoxic/ischemic PC.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Rybnikova E,Tulkova E,Pelto-Huikko M,Samoilov Mdoi
10.1016/s0304-3940(02)00577-3keywords:
subject
Has Abstractpub_date
2002-08-23 00:00:00pages
49-52issue
1eissn
0304-3940issn
1872-7972pii
S0304394002005773journal_volume
329pub_type
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