Overexpression of nerve growth factor in epidermis of transgenic mice preserves excess sensory neurons but does not alter the somatotopic organization of cutaneous nerve projections.

abstract：:We have identified the secretory cleavage site in the Alzheimer amyloid precursor (APP) in a non-transfected neuronal cell line, using cyanogen bromide digests of APP purified from medium conditioned by PC-12 cells which were differentiated to a neuronal phenotype. The results obtained are most consistent with proteol...

journal_title：Neuroscience letters

authors： Anderson JP,Esch FS,Keim PS,Sambamurti K,Lieberburg I,Robakis NK

更新日期：1991-07-08 00:00:00

abstract：:In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e. von Willebrand factor and CD34), as well as morphologic...

journal_title：Neuroscience letters

authors： Zhang HF,Liang GB,Zhao MG,Song ZQ,Xu ZH

更新日期：2013-08-26 00:00:00

abstract：:Variation in AKT1 has been associated with schizophrenia, bipolar disease and type II diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's disease (PD). We performed a case-control association analysis of AKT1 in a Greek cohort of PD u...

journal_title：Neuroscience letters

authors： Xiromerisiou G,Hadjigeorgiou GM,Papadimitriou A,Katsarogiannis E,Gourbali V,Singleton AB

更新日期：2008-05-09 00:00:00

abstract：:Melatonin is the principle hormonal product of the pineal gland. It is secreted with a robust daily rhythm, peaking near the middle of the night. During the daytime, concentrations remain very low, as exposure to light robustly suppresses its secretion. The regulation of melatonin by light is well-characterized, but a...

journal_title：Neuroscience letters

authors： Bedrosian TA,Herring KL,Walton JC,Fonken LK,Weil ZM,Nelson RJ

更新日期：2013-05-10 00:00:00

abstract：:Calcium antagonists inhibit both the Ca2(+)-dependent and -independent release of endogenous glutamate from intact synaptosomes. In the present study, the inhibitory potency of several different classes of calcium antagonists were determined under conditions that control for an effect of these compounds on the Ca2(+)-...

journal_title：Neuroscience letters

authors： Terrian DM,Dorman RV,Gannon RL

更新日期：1990-11-13 00:00:00

abstract：:To determine the involvement of the medial prefrontal cortex (mPFC) in operant-type delayed alternation, microinjections of muscimol into the mPFC were used for temporal inactivation during behavioral tests in rats. The temporal mPFC inactivation showed effects related to both dorsal (decreased delay-dependent correct...

journal_title：Neuroscience letters

authors： Izaki Y,Maruki K,Hori K,Nomura M

更新日期：2001-11-27 00:00:00

abstract：:Using the novel substituted benzamide drug [3H]raclopride in combination with in vitro receptor autoradiography, the distribution of dopamine D-2 receptors was studied in the monkey brain. Highest densities of D-2 receptors are present in dopamine-rich areas and the distribution shows the following rank order: caudatu...

journal_title：Neuroscience letters

authors： Köhler C,Radesäter AC

更新日期：1986-05-06 00:00:00

abstract：:Responses of single neurones to vibrissal stimulation and to the iontophoretically applied putative neurotransmitters, L-glutamate and L-aspartate, were recorded in the trigeminal nucleus caudalis of the rat. Vibrissal responses were unaffected by the specific N-methyl-D-aspartate receptor antagonist, D-alpha-aminoadi...

journal_title：Neuroscience letters

authors： Salt TE,Hill RG

更新日期：1981-03-10 00:00:00

abstract：:Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In th...

journal_title：Neuroscience letters

authors： Cheepudomwit T,Güzelsu E,Zhou C,Griffin JW,Höke A

更新日期：2008-01-17 00:00:00

abstract：:The effect of various ionic solutions microinjected into the nucleus tractus solitarii (NTS) on blood pressure, heart rate and respiration rate was investigated in urethane-anesthetized rats. Unilateral microinjection of solutions containing NaCl (154 mM), NaCl (154 mM) and KCl (2.8 mM) or NaNO3 (154 mM) into a restri...

journal_title：Neuroscience letters

authors： Lukovic L,de Jong W

更新日期：1990-03-02 00:00:00

abstract：:Adult observers can quickly identify specific actions performed by an invisible actor from the points of lights attached to the actor's head and major joints. Infants are also sensitive to biological motion and prefer to see it depicted by a dynamic point-light display. In detecting biological motion such as whole bod...

journal_title：Neuroscience letters

authors： Ichikawa H,Kanazawa S,Yamaguchi MK,Kakigi R

更新日期：2010-09-27 00:00:00

abstract：:Dopamine metabolism and release were determined in the striata of rats sustaining varying damage to the nigrostriatal dopamine (DA) projection. DA metabolism, inferred from concentrations of dihydroxy-phenylacetic acid (DOPAC) or homovanillic acid (HVA), decreased with DA denervation of more than 20%. Dopamine release...

journal_title：Neuroscience letters

authors： Altar CA,Marien MR

更新日期：1989-01-30 00:00:00

abstract：:Protein kinase C (PKC) pathway plays important roles in different phenomena in nervous system development. Our previous data demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment, a PKC activator, for 48 h decreases retinal cells proliferation by a mechanism mediated by muscarinic receptor activation, invo...

journal_title：Neuroscience letters

authors： Braga LE,Granja MG,da Silva GM,Giestal-de-Araujo E,dos Santos AA

更新日期：2013-08-29 00:00:00

abstract：:The effects of several Ca2+ channel blockers were evaluated on inhibitory junction potential (IJP) evoked in rat colonic circular muscle by electrical field stimulation (EFS). Glass microelecrodes were used to record membrane potential of smooth muscle cells. IJPs were tetrodotoxin-sensitive (1 microM) and disappeared...

journal_title：Neuroscience letters

authors： Borderies JR,Jiménez M,Angel F

更新日期：1996-05-31 00:00:00

abstract：:Theta rhythms in the hippocampus are believed to be the "metric" relating to various behavior patterns for free roaming rats. In this study, the theta rhythms were studied while rats either walked or were passively translated by a toy car on a linear track (referred to as WALK and TRANS respectively). For the similar ...

journal_title：Neuroscience letters

authors： Xie K,Yan Y,Fang X,Gao S,Hong B

更新日期：2012-04-25 00:00:00

abstract：:Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adul...

journal_title：Neuroscience letters

authors： Martinez A,Vitórica J,Satrústegui J

更新日期：1988-06-07 00:00:00

abstract：:Kynurenic acid (KYNA), a neuroactive metabolite of tryptophan that acts on different receptors (e.g. those of N-methyl-D-aspartate (NMDA) and presynaptic α7 nicotinic acetylcholine (nACh)), exerts fundamentally antiglutamatergic effects. In view of its antiglutamatergic properties, an elevation of the KYNA level withi...

journal_title：Neuroscience letters

authors： Demeter I,Nagy K,Farkas T,Kis Z,Kocsis K,Knapp L,Gellert L,Fülöp F,Vecsei L,Toldi J

更新日期：2013-10-11 00:00:00

abstract：:Serotonin-immunoreactive (5HT-IR) neurons were investigated in the brain and rostral (cervical) spinal cord of the garfish, a non-teleost actinopterygian. The diencephalon contained a prominent 5HT-IR cell group consisting mainly of liquor-contacting neurons in the hypothalamic periventricular wall. Their ependymofuga...

journal_title：Neuroscience letters

authors： Chiba A,Oka S

更新日期：1999-02-12 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid [+/-)-2-APV) and kynurenic acid both suppressed spontaneous epileptiform burst discharges in the CA3 region of rat hippocampal slices. When the bursts were induced by perfusion with magnesium-free medium (+/-)-2-APV was the more potent in...

journal_title：Neuroscience letters

authors： Stone TW

更新日期：1988-01-22 00:00:00

abstract：:The aim of this study was to examine the ability of somatostatin receptor (sst(1)) to regulate the release of somatostatin in rat retina. Immunohistochemistry studies were performed to locate the somatostatin neurons, and radioligand binding to ascertain the presence of sst(1). The neuronal release of somatostatin was...

journal_title：Neuroscience letters

authors： Mastrodimou N,Thermos K

更新日期：2004-02-06 00:00:00

abstract：:By means of extracellular recordings, we studied thalamic ventrobasal complex neurons of rats tested first awake, and then anesthetized with pentobarbital. In both conditions, we found two groups of units in both states. The first group, displaying a spontaneous bursting activity, was not obviously responding to perip...

journal_title：Neuroscience letters

authors： Montagne-Clavel J,Olivéras JL

更新日期：1995-08-18 00:00:00

abstract：:Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

journal_title：Neuroscience letters

authors： Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

更新日期：2005-12-30 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is known as a neuro-survival factor in the developing and developed CNS, as well as in the CNS following injury. However, little is known about the expression of CNTF or that of its receptor (CNTFR-alpha) in cases of intracerebral hemorrhage (ICH). We investigated the temporal and sp...

journal_title：Neuroscience letters

authors： Yokota H,Yoshikawa M,Hirabayashi H,Nakase H,Uranishi R,Nishimura F,Sugie Y,Ishizaka S,Sakaki T

更新日期：2005-04-04 00:00:00

abstract：:Carbonic anhydrase (CA) activity was localized histochemically in the retina and brain of the honeybee drone. A positive reaction that could be inhibited with 10(-5) M acetazolamide was found only in brain glial cells such as those in the lamina and medulla of the optic lobes. In the retina, neither the photoreceptors...

journal_title：Neuroscience letters

authors： Walz B

更新日期：1988-02-15 00:00:00

abstract：:The septins, which form a conserved family of cytoskeletal GTP-binding proteins in mammals, comprise stable heteromeric complexes and have diverse roles in protein scaffolding, cytokinesis, vesicle trafficking and plasma membrane integrity following cell division. The goal of this study was to determine the localizati...

journal_title：Neuroscience letters

authors： Hara A,Taguchi A,Niwa M,Aoki H,Yamada Y,Ito H,Nagata K,Kunisada T,Mori H

更新日期：2007-08-23 00:00:00

abstract：:Presenilin 1 mutations are the major cause of autosomal dominant Alzheimer's disease. Here we present evidence that pathogenic mutations in putative transmembrane domains 1, 2, 3, 4 and 6 align along helical faces, thus supporting the view that these are indeed transmembrane domains, and suggesting that disruption of ...

journal_title：Neuroscience letters

authors： Hardy J,Crook R

更新日期：2001-06-29 00:00:00

abstract：:The purpose of this investigation was to evaluate the effect and mechanisms of electroacupuncture (EA) at the bilateral Zusanli acupoints (ST-36) on glucose tolerance in normal rats. Intravenous glucose tolerance test (IVGTT) was performed to examine the effects of electroacupuncture (EA) on glucose tolerance in rats....

journal_title：Neuroscience letters

authors： Lin RT,Chen CY,Tzeng CY,Lee YC,Cheng YW,Chen YI,Ho WJ,Cheng JT,Lin JG,Chang SL

更新日期：2011-04-25 00:00:00

abstract：:We have demonstrated the existence and localization of two angiotensin II (AII) receptor subtypes in different regions of the rat brain using competitive radioligand binding technique. The identification of the subtypes was made by the reciprocal selectivity of DuP 753 and PD123177 for the AII-1 and AII-2 receptors, r...

journal_title：Neuroscience letters

authors： Leung KH,Smith RD,Pieter,Timmermans BM,Chiu AT

更新日期：1991-02-11 00:00:00

abstract：:In control samples, intense acoustic "go" stimuli accelerate the central and peripheral motor processes that compose simple reaction time movements. The goal of the current study was to determine whether movements that are initiated to intense acoustic cues facilitate simple reaction times in (1) adults with chronic s...

journal_title：Neuroscience letters

authors： Coombes SA,Janelle CM,Cauraugh JH

更新日期：2009-03-13 00:00:00

abstract：:We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertica...

journal_title：Neuroscience letters

authors： Veber D,Mutti E,Sironi L,Guerrini U,Gianazza E,Scalabrino G

更新日期：2008-08-08 00:00:00