Vasoactive intestinal polypeptide facilitates muscarinic transmission in mammalian sympathetic ganglia.

Abstract:

:Vasoactive intestinal polypeptide (VIP) in the concentration of 1 microM or less markedly and selectively increased the amplitude and duration of the muscarinic slow excitatory postsynaptic potential (EPSP) without appreciably affecting the nicotinic fast EPSP or the non-cholinergic EPSP of guinea pig inferior mesenteric ganglion cells. The membrane depolarization evoked by the muscarinic agonist, acetyl-beta-methylcholine in these neurons was similarly enhanced by VIP. Our results suggest that the peptide may be a neuromodulator effective in enhancing the sensitivity of postsynaptic muscarinic receptors to acetylcholine in the vertebrate sympathetic ganglia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Mo N,Dun NJ

doi

10.1016/0304-3940(84)90344-6

subject

Has Abstract

pub_date

1984-11-23 00:00:00

pages

19-23

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(84)90344-6

journal_volume

52

pub_type

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