Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress.

Abstract:

:Oligodendrocyte precursor cells (OPCs) play critical roles in maintaining the number of oligodendrocytes in white matter. Previously, we have shown that oxidative stress dampens oligodendrocyte regeneration after white matter damage, while a clinically proven radical scavenger, edaravone, supports oligodendrocyte repopulation. However, it is not known how edaravone exerts this beneficial effect against oxidative stress. Using in vivo and in vitro experiments, we have examined whether edaravone exhibits direct OPC-protective effects. For in vivo experiments, prolonged cerebral hypoperfusion was induced by bilateral common carotid artery stenosis in mice. OPC damage was observed on day 14 after the onset of cerebral hypoperfusion, and edaravone was demonstrated to decrease OPC death in cerebral white matter. In vitro experiments also confirmed that edaravone reduced oxidative-stress-induced OPC death. Because white matter damage is a major hallmark of many neurological diseases, and OPCs are instrumental in white matter repair after injury, our current study supports the idea that radical scavengers may provide a potential therapeutic approach for white matter related diseases.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Takase H,Liang AC,Miyamoto N,Hamanaka G,Ohtomo R,Maki T,Pham LD,Lok J,Lo EH,Arai K

doi

10.1016/j.neulet.2018.01.018

subject

Has Abstract

pub_date

2018-03-06 00:00:00

pages

120-125

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(18)30018-1

journal_volume

668

pub_type

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