Abstract:
:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5-dimethoxyamphetamine (DOC), a psychedelic substance that is structurally related to amphetamine, and AH-7921, an opioid analgesic that is used for recreational purposes and has a potency similar to that of morphine. Currently, scientific evidence for the dependence liability or toxicity of NPSs is lacking. Therefore, in this study, we performed animal behavioral tests to evaluate the dependence liability of DOC and AH-7921. The rewarding and reinforcing effects of DOC and AH-7921 were evaluated using the conditioned place preference (CPP) paradigm in mice and the self-administration (SA) procedure in rats. Both DOC and AH-7921 increased the preference for the drug-paired compartment in the CPP test at a dose of 0.3 mg/kg and increased the number of responses to the active lever in the SA test at 0.01 mg/(kg·infusion). Collectively, the data suggest that DOC and AH-7921 may have both rewarding and reinforcing effects. Further studies are needed to confirm the reinforcing effects in broader dose ranges with various schedules.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SKdoi
10.1016/j.neulet.2018.04.009subject
Has Abstractpub_date
2018-05-29 00:00:00pages
66-70eissn
0304-3940issn
1872-7972pii
S0304-3940(18)30264-7journal_volume
676pub_type
杂志文章abstract::Depression associated with diabetes has been described as a highly debilitating comorbidity. Due to its complex and multifactorial mechanisms, the treatment of depression associated with diabetes represents a clinical challenge. Cannabidiol (CBD), the non-psychotomimetic compound derived from Cannabis sativa, has been...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2018.06.006
更新日期:2018-08-24 00:00:00
abstract::CREATE (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) is a pedagogical approach for teaching and learning science through the rigorous analysis of primary scientific literature. This mini-review focuses on the tools, assignments, and in-class activities by which this s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135532
更新日期:2021-01-18 00:00:00
abstract::The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to those of L-glutamate and are widely regarded as bona fide transmitter candidates. In this study, L-cysteine sulphinic acid, L-cysteic acid, DL-homocysteic acid and L-homocysteine sulphinic acid were investigated for their abili...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90175-k
更新日期:1993-05-14 00:00:00
abstract::PC12 rat pheochromocytoma cells undergo programmed cell death or apoptosis with DNA fragmentation when deprived of serum. Here, we isolated a subclone of PC12, PC12FrR, that was resistant to DNA fragmentation in a serum-free condition. PC12FrR grew slightly faster, and had cells that were slightly larger than parental...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11585-k
更新日期:1995-05-26 00:00:00
abstract::Amyloid beta-protein, the major constituent of Alzheimer's disease (AD) brain amyloid deposits, is encoded by several alternatively spliced amyloid precursor protein (APP) mRNAs. The well-established associated in Down's syndrome (DS) between APP overproduction and premature development of AD, as well as the recent de...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11681-l
更新日期:1995-06-30 00:00:00
abstract::We studied event-related desynchronization (ERD) of the 8-13 Hz rhythm (mu rhythm) of the primary somatosensory cortex (SI) caused by contra- and ipsilateral median-nerve stimulation. We used whole-head magnetoencephalography (MEG) and wavelet analysis together with our newly developed color-coded single-trial ERD dis...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01562-7
更新日期:2000-11-24 00:00:00
abstract::Several lines of evidence suggest a physiological role for Cu2+ in regulating nervous system function. In the present study using whole-cell patch-clamp recording, Cu2+ greatly enhanced current activated by 10 microM ATP in the majority of rat nodose ganglion neurons. The enhancement was concentration-dependent betwee...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)13186-4
更新日期:1996-11-15 00:00:00
abstract::Olivary hypertrophy, a combined retrograde and transneuronal reaction, is found in cells of the inferior olive after cerebellar ablation in the cat. Its chief features are central chromatolysis and hypertrophy of the peripherally located granular endoplasmatic reticulum with accumulation of electron-dense material in ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90399-4
更新日期:1985-10-24 00:00:00
abstract::Functioning of the hypothalamo-pituitary-adrenocortical axis was assessed in rats treated with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), a selective noradrenergic neurotoxin. Although adrenal weights were slightly increased 10 days after DSP-4 injection, basal plasma corticosterone levels were unaltered co...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90111-3
更新日期:1984-05-18 00:00:00
abstract::The ability in vivo of the muscarinic agonist, pilocarpine, to increase phosphoinositol (PI) hydrolysis in lithium pretreated rats was investigated by measuring the accumulation of [(3)H]inositol phosphates (IP). As expected, 20 mg/kg s.c. pilocarpine, a muscarinic agonist, increased PI hydrolysis in the striatum, fro...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01023-5
更新日期:2000-05-05 00:00:00
abstract::Multiple sclerosis (MS) is a chronic inflammatory CNS disorder, resulting in progressive neurological dysfunction. The disease has a higher incidence in Caucasian Americans (CA) than African Americans (AA); however, the latter may have a more aggressive disease course. We used cluster analysis to determine whether the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.12.049
更新日期:2007-02-27 00:00:00
abstract::On anesthetized adult rats, we examined the possibility that the discharges of spinocerebellar Purkinje cells (PCs) are modulated by passive limb positioning. The rat forelimb was passively placed in four different sagittal positions while the simple spike spontaneous activity of single PCs was recorded; recordings st...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00185-2
更新日期:1998-04-03 00:00:00
abstract::The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90439-1
更新日期:1983-06-30 00:00:00
abstract::The clinical efficacy of clozapine in treating schizophrenia may stem from its lack of receptor selectivity. If true, several clozapine-sensitive receptors may be co-expressed by neurons dysfunctional in schizophrenia. To test this hypothesis, neurons from the rat medial prefrontal cortex were acutely isolated and sub...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00882-9
更新日期:1998-12-24 00:00:00
abstract::Acute stress can provoke apoptosis of the retina cells, and up-regulation of calcitonin gene related peptide (CGRP) in retina. However the role of CGRP in the pathology of the stress induced apoptosis of the retina cells is still elusive. The aim of this study was to investigate the endogenous of CGRP on retinal cell ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.06.049
更新日期:2011-08-26 00:00:00
abstract::Normal rats tend to respond to a sudden burst of noise or flash of light with slightly less startle when they are engaged in active behaviour at the time of presentation. This effect is vastly more pronounced in animals with lesions of the superior colliculus. These results are taken as support for a theory implicatin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(75)90022-1
更新日期:1975-12-01 00:00:00
abstract::Five monkeys vocalizing at self-pace (self-paced vocalization) were well trained to vocalize in response to a monkey call (audio-initiated vocalization). Field potentials associated with audio-initiated vocalizations were recorded by using electrodes which were implanted chronically on the surface and at a 2.0-3.0 mm ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00570-4
更新日期:1999-09-03 00:00:00
abstract::This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.07.043
更新日期:2012-09-06 00:00:00
abstract::We have examined the effect of ouabain, a Na,K-ATPase inhibitor known to secondarily increase intracellular Ca2+ levels, on evoked (phasic) transmitter release at the frog neuromuscular junction. As had been reported previously, we observed an increase in both spontaneous and evoked release with prolonged exposure to ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90104-x
更新日期:1994-06-06 00:00:00
abstract::Mouse neuroblastoma x rat glioma hybrid cells (N x G, NG108-15) were used to study the mechanism of Ca(2+)-current (ICa) inhibition by 5-hydroxytryptamine (5-HT). 5-HT caused a dose-dependent decrease of ICa which was abolished by ICS 205-930 (10)(-8) M) while 2-methyl-5-HT was an agonist. Intracellular infusion of GD...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90068-v
更新日期:1993-04-16 00:00:00
abstract::The transcriptional co-activator p300 plays an important role in regulating gene expression in a number of different cell types. We have shown that wild type (WT) Presenilin 1 (PS1) stimulates the transcriptional activity ability of CREB Binding Protein (CBP), a close homolog of p300, whereas the Alzheimer's disease (...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.11.036
更新日期:2007-02-14 00:00:00
abstract::Expiratory only resistive loaded breathing (RL) reduces high energy electromyogram (EMG) power (EH) during an isometric contraction of a leg extensor muscle, but not an arm flexor. An interaction between afferent activity during expiratory RL and inspiratory non-loaded phases of breathing, which the contraction spanne...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01620-7
更新日期:2000-12-15 00:00:00
abstract::Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to antipsychotic therapy is highly variable, yet prognostic biomarkers are lacking. The aim of the study was to investigate the association of 14 singl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2018.08.002
更新日期:2018-09-14 00:00:00
abstract::Rat brain slices containing the nucleus tractus solitarius loaded with [3H]5-hydroxytryptamine ([3H]5-HT) for superfusion were stimulated at (3 Hz, 25 mA, 1 min) resulting in fractional release ratios S2/S1 of 0.89 for [3H]5-HT in the presence of the serotonin uptake inhibitor 1.0 microM 6-nitroquipazine (6-NQ). alpha...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11450-b
更新日期:1995-04-14 00:00:00
abstract::For a flickering light with two or more frequency components, the temporal envelope of the flickering light is perceived, although there is no frequency component at the frequency of the envelope. To address the processing of the temporal envelope, we compared cortical responses to the envelope of amplitude-modulated ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.10.024
更新日期:2011-01-07 00:00:00
abstract::The present study was designed to address the role of macrophages in Mn-induced neurotoxicity and to test the hypothesis that minocycline, a tetracycline derivative, attenuates the biochemical and morphological sequelae of Mn. Mn was unilaterally microinjected into rat nigra followed by systemic minocycline or saline ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.10.066
更新日期:2012-01-06 00:00:00
abstract::This study aimed to determine whether neuropathic pain is associated with a plasticity change in the number of synapses in the spinal dorsal horn. 12 normal adult SD rats were randomly divided into two groups: 7 animals were subjected to unilateral loose ligation (to induce chronic constriction injury) of the sciatic ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.09.037
更新日期:2010-12-03 00:00:00
abstract::Interhemispheric coherence for 19 channel EEG activity collected over a three year period from 184 men and women who relaxed in a quiet, darkened chamber showed significant increased coherence between caudal temporal regions for the 11 Hz frequency band during increased (>∼8 nT) global geomagnetic activity at the time...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.11.024
更新日期:2014-02-07 00:00:00
abstract::A comparative study was made of the enzyme choline acetyltransferase (ChAT) from normal and Alzheimer (senile dementia of the Alzheimer type) brain. The number of molecular weight and charge forms of the enzyme were determined in the caudate region of both brains. Efficient purification of active ChAT was achieved usi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90195-8
更新日期:1985-08-30 00:00:00
abstract::We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90475-8
更新日期:1989-08-14 00:00:00