Molecular target size of an L-glutamate receptor from the cockroach central nervous system.

Abstract:

:L-Glutamate binding to cockroach central nervous system (CNS) membranes is unaffected by freeze-drying and subsequent rehydration. The dissociation constant is similarly unaltered by irradiation at a dose of 3 Mrad which affects only the number of biologically active binding sites. A molecular weight estimate for this insect CNS L-glutamate receptor was performed using irradiation inactivation analysis. By this method a molecular target size of approximately 77.8 kDa was determined. This figure is in agreement with the molecular weight found by other authors for L-glutamate binding sites in the rat brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sepúlveda MI,Sattelle DB

doi

10.1016/0304-3940(89)90686-1

subject

Has Abstract

pub_date

1989-05-22 00:00:00

pages

210-4

issue

1-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90686-1

journal_volume

100

pub_type

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