Abstract：
:X-box binding protein 1 (XBP1), a critical gene in the endoplasmic reticulum stress response, is located on chromosome 22q12, which has been linked with bipolar disorders in several studies. Recently, associations have been reported between a polymorphism (-116C --> G) in the promoter region of XBP1, and bipolar disorders in both case-control study and family-based association study, however, this finding is not yet confirmed by other research using independent sample populations. To replicate this finding and determine the association between onset age of bipolar disorders and the XBP1 C--116G polymorphism, we investigated the prevalence of this polymorphism in a Chinese population (153 bipolar disorder patients and 174 controls). We were unable, however, to demonstrate a significant association between the C--116G polymorphism and bipolar disorders (P = 0.674 for genotype and P = 0.436 for allele frequency) or age at onset (P = 0.563). Further, no association was demonstrated between this polymorphism and family history in bipolar disorder patients. These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hou SJ,Yen FC,Cheng CY,Tsai SJ,Hong CJdoi
10.1016/j.neulet.2004.06.012keywords:
subject
Has Abstractpub_date
2004-09-02 00:00:00pages
232-4issue
2eissn
0304-3940issn
1872-7972pii
S0304394004007463journal_volume
367pub_type
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