Abstract：
:The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. These include anandamide, oleoyl ethanolamide and palmitoyl ethanolamide, and their effects are mediated by a variety of downstream targets including cannabinoid receptors and peroxisome proliferator-activated receptors (PPARs). Activation of both of these may have anti-inflammatory and neuroprotective effects. Levels of all three mediators are low in normal nervous tissue, but substantially elevated in mice lacking FAAH as a result of genetic deletion. There is a long anecdotal history of cannabis use by patients suffering from multiple sclerosis, and preclinical studies have indicated beneficial effects of cannabinoid receptor stimulation on both long-term outcome and acute muscle spasm in rodent models of multiple sclerosis (experimental autoimmune encephalitis; EAE). Thus far no report has appeared on the effect of inhibition of FAAH on the progression of EAE. Using a chronic mouse EAE model, we present data indicating that mice lacking FAAH experience an initial inflammatory phase of EAE similar in severity to wild type controls, but exhibited a more substantial clinical remission compared to wild type mice.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Webb M,Luo L,Ma JY,Tham CSdoi
10.1016/j.neulet.2008.04.090subject
Has Abstractpub_date
2008-07-04 00:00:00pages
106-10issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(08)00571-5journal_volume
439pub_type
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：2019-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2013-09-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)12445-9
更新日期：1996-03-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2001-10-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.01.054
更新日期：2008-03-28 00:00:00
