Abstract:
:Dopaminergic neurons of the goldfish retina were selectively destroyed after a single intravitreal injection of 1-methyl-4-phenylpyridinium ion (MPP+). The ultrastructural analysis of the retina 3 days after toxin administration shows darkening of some retinal neurons present in the inner nuclear layer including their cytoplasmic processes. Both uptake and release of dopamine were reduced in the toxin-injected retina, whereas choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities, as well as the uptake of D-[3H]aspartate were not affected.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Villani L,Poli A,Bissoli R,Barnabei Odoi
10.1016/0304-3940(88)90565-4subject
Has Abstractpub_date
1988-03-31 00:00:00pages
167-72issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(88)90565-4journal_volume
86pub_type
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