Neurotoxic effect of 1-methyl-4-phenylpyridinium ion on dopaminergic neurons of the retina of goldfish.

Abstract:

:Dopaminergic neurons of the goldfish retina were selectively destroyed after a single intravitreal injection of 1-methyl-4-phenylpyridinium ion (MPP+). The ultrastructural analysis of the retina 3 days after toxin administration shows darkening of some retinal neurons present in the inner nuclear layer including their cytoplasmic processes. Both uptake and release of dopamine were reduced in the toxin-injected retina, whereas choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities, as well as the uptake of D-[3H]aspartate were not affected.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Villani L,Poli A,Bissoli R,Barnabei O

doi

10.1016/0304-3940(88)90565-4

subject

Has Abstract

pub_date

1988-03-31 00:00:00

pages

167-72

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90565-4

journal_volume

86

pub_type

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