Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis.

abstract：:Many researchers have investigated the variability of discrete goal-directed movements. However, a possible time-dependent property for them has been ignored. We investigated the time-dependent property of the kinematic variability in human rapid goal-directed movements by using fractal analysis. The variability of th...

journal_title：Neuroscience letters

authors： Miyazaki M,Kadota H,Kudo K,Masani K,Ohtsuki T

更新日期：2001-05-25 00:00:00

abstract：:When reaching to remembered target locations following an intervening eye movement a systematic pattern of error is found indicating eye-centred updating of visuospatial memory. Here we investigated if implicit targets, defined only by allocentric visual cues, are also updated in an eye-centred reference frame as expl...

journal_title：Neuroscience letters

authors： Thompson AA,Glover CV,Henriques DY

更新日期：2012-04-18 00:00:00

abstract：:The effects of systemic hypothermia (33.5 degrees C) on the ischemia-evoked release of the neurotransmitter amino acids, glutamate, aspartate, gamma-amino-butyric acid (GABA) and glycine into rat cerebral cortical superfusates were evaluated in the rat four vessel occlusion model. Glutamate, aspartate and GABA, but no...

journal_title：Neuroscience letters

authors： Simpson RE,Walter GA,Phillis JW

更新日期：1991-03-11 00:00:00

abstract：:Psychotic symptoms are common in individuals with Alzheimer's disease (AD), and define a phenotype associated with more rapid cognitive and functional decline. Evidence suggests that psychotic symptoms may be influenced by genetic factors, and recent studies in schizophrenia, bipolar affective disorder (BPAD) and Alzh...

journal_title：Neuroscience letters

authors： Sims R,Hollingworth P,Moskvina V,Dowzell K,O'Donovan MC,Powell J,Lovestone S,Brayne C,Rubinsztein D,Owen MJ,Williams J,Abraham R

更新日期：2009-09-11 00:00:00

abstract：:The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, ...

journal_title：Neuroscience letters

authors： Bergamaschi S,Binetti G,Govoni S,Wetsel WC,Battaini F,Trabucchi M,Bianchetti A,Racchi M

更新日期：1995-12-01 00:00:00

abstract：:The distribution of astrocytes has been studied in whole-mounted horse and monkey retinae by the immunocytochemical localization of glial fibrillary acidic protein (GFAP). In the horse, astrocytes were found to be restricted to a narrow zone close to the optic nerve head. This is also the only region of the horse reti...

journal_title：Neuroscience letters

authors： Schnitzer J

更新日期：1987-07-09 00:00:00

abstract：:To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the e...

journal_title：Neuroscience letters

authors： Tokuda T,Tanaka K,Kametani F,Ikeda S,Yanagisawa N

更新日期：1995-02-17 00:00:00

abstract：:We used the mismatch negativity event-related potential to examine how spatial location and feature variation affect the capacity of the auditory system to automatically respond to pairs of rapid (180 ms apart) acoustic changes within a single tone. When a tone first deviated from a standard tone in source location an...

journal_title：Neuroscience letters

authors： Deouell LY,Karns CM,Harrison TB,Knight RT

更新日期：2003-01-02 00:00:00

abstract：:We identified a 45-kDa protein by 2D electrophoresis that was enhanced following pentylenetetrazol (PTZ)-mediated seizures. Mass-spectrography of this protein revealed the beta subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKIIbeta), although no evidence for increase in bulk CaMKIIbeta transcripts was obta...

journal_title：Neuroscience letters

authors： Matsu-ura T,Nakadai T,Oda Y,Nagasu T,Mikoshiba K,Tamura TA

更新日期：2002-04-12 00:00:00

abstract：:To determine whether mutations in the coding region of the alpha-synuclein gene are relevant in cases of multiple system atrophy (MSA), detailed nucleotide sequence analysis of the alpha-synuclein gene was performed using total RNA obtained from autopsied brain specimens of 11 pathologically confirmed cases of MSA. Th...

journal_title：Neuroscience letters

authors： Ozawa T,Takano H,Onodera O,Kobayashi H,Ikeuchi T,Koide R,Okuizumi K,Shimohata T,Wakabayashi K,Takahashi H,Tsuji S

更新日期：1999-07-30 00:00:00

abstract：:The ability to extract invariant relationships from physically varying stimulation is critical for example to categorical perception of complex auditory information such as speech and music. Human subjects were presented with tone pairs randomly varying over a wide frequency range, there being no physically constant t...

journal_title：Neuroscience letters

authors： Paavilainen P,Jaramillo M,Näätänen R,Winkler I

更新日期：1999-04-23 00:00:00

abstract：:Because of their limited regenerative potential, cochlear hair cell loss is one of the major causes of permanent hearing loss in mammals. However, recent studies have shown that postnatal cochlear epithelia retain the progenitor cells that form otospheres. Otospheres are capable of self-renewing and differentiating in...

journal_title：Neuroscience letters

authors： Lou XX,Nakagawa T,Ohnishi H,Nishimura K,Ito J

更新日期：2013-02-08 00:00:00

abstract：:Recent studies suggest that mild hypothermia significantly alleviate damage following cerebral ischemia though the precise mechanism is poorly defined. In the present study, middle cerebral artery occlusion (MCAo) was induced in Sprague-Dawley (SD) rats for 1 h followed by varying periods of reperfusion. Cerebral infa...

journal_title：Neuroscience letters

authors： Prakasa Babu P,Yoshida Y,Su M,Segura M,Kawamura S,Yasui N

更新日期：2000-09-22 00:00:00

abstract：:For a flickering light with two or more frequency components, the temporal envelope of the flickering light is perceived, although there is no frequency component at the frequency of the envelope. To address the processing of the temporal envelope, we compared cortical responses to the envelope of amplitude-modulated ...

journal_title：Neuroscience letters

authors： Okamoto Y,Nakagawa S

更新日期：2011-01-07 00:00:00

abstract：:Against the current concept of abortive regeneration of axotomized neurons in the mammalian central nervous system, the occurrence of remarkable axonal regeneration of cerebellothalamic projection neurons following transection of the decussation of the superior cerebellar peduncle was proved in kittens morphologically...

journal_title：Neuroscience letters

authors： Kawaguchi S,Miyata H,Kawamura M,Harada Y

更新日期：1981-08-07 00:00:00

abstract：:Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and mig...

journal_title：Neuroscience letters

authors： Hung CF,Lung FW,Chen CH,O'Nions E,Hung TH,Chong MY,Wu CK,Wen JK,Lin PY

更新日期：2011-10-31 00:00:00

abstract：:Afferent fibers ending in nerve-end neuromas generate spontaneous impulse discharge which has been implicated as a cause of paraesthesias and pain following peripheral nerve injury in man. We now show in rats that the anticonvulsant drug phenytoin (PT), applied systemically or topically onto desheathed neuromas, suppr...

journal_title：Neuroscience letters

authors： Yaari Y,Devor M

更新日期：1985-07-04 00:00:00

abstract：:The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultu...

journal_title：Neuroscience letters

authors： Li RX,Yu XZ,Fu M,Zong M,Liu RL,Xie ZP

更新日期：2008-08-15 00:00:00

abstract：:Astrocytes have been implicated in axon guidance and synaptic regeneration in the retina and these processes involve activation of the high affinity nerve growth factor receptor, known as the tyrosine kinase A (TrkA) receptor. The purpose of the present study was to characterize the expression of TrkA in astrocytes of...

journal_title：Neuroscience letters

authors： Ruiz-Ederra J,Hitchcock PF,Vecino E

更新日期：2003-02-13 00:00:00

abstract：:Leucine-rich glioma inactivated 3 (LGI3) is a member of LGI/epitempin (EPTP) family. The biological function of LGI3 and its association with disease are not known. We previously reported that mouse LGI3 was highly expressed in brain in a developmentally and transcriptionally regulated manner. In this study, we identi...

journal_title：Neuroscience letters

authors： Park WJ,Lee SE,Kwon NS,Baek KJ,Kim DS,Yun HY

更新日期：2008-10-31 00:00:00

abstract：:The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...

journal_title：Neuroscience letters

authors： Devor M

更新日期：1983-09-30 00:00:00

abstract：:Neuronal recording and neuroimaging studies have shown that the primary motor area (M1) not only participates in motor execution, but is also engaged during movement preparation. The purpose of the present study was to map the distribution of the preparation- and execution-related activity within the contralateral M1 ...

journal_title：Neuroscience letters

authors： Zang Y,Jia F,Weng X,Li E,Cui S,Wang Y,Hazeltine E,Ivry R

更新日期：2003-02-06 00:00:00

abstract：:Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (...

journal_title：Neuroscience letters

authors： Henke H

更新日期：1979-10-01 00:00:00

abstract：:Excitotoxin lesion of nucleus basalis with kainate or ibotenate results in degeneration of cholinergic neurones and a subsequent cholinergic deficit in cerebral cortex ipsilateral to the lesion. This lesion is accompanied by a massive increase in ornithine decarboxylase (ODC) activity in ipsilateral cortex, which was ...

journal_title：Neuroscience letters

authors： Wood H,de Belleroche J

更新日期：1990-03-26 00:00:00

abstract：:This work investigates the design of a new method to evaluate the importance of visual elements taken into account by a handball goalkeeper facing a thrower. Virtual reality was used to design and reproduce standardised situations in a controlled environment. Under such conditions, it was possible to isolate for inves...

journal_title：Neuroscience letters

authors： Bideau B,Multon F,Kulpa R,Fradet L,Arnaldi B,Delamarche P

更新日期：2004-11-30 00:00:00

abstract：:This study aims to investigate the relationship between DNA methylation and expression of human dopamine transporter (hDAT). We examined methylation status of hDAT in cells with various hDAT expression levels, including two dopaminergic neural cell lines (SK-N-AS and SH-SY-5Y) and one non-dopaminergic cell line (HEK29...

journal_title：Neuroscience letters

authors： Zhai D,Li S,Dong G,Zhou D,Yang Y,Wang X,Zhao Y,Yang Y,Lin Z

更新日期：2018-01-01 00:00:00

abstract：:The displaced retinal ganglion cells in normal rats and rats with left eye enucleated at birth were studied using the fluorescent dye Fast blue as neuronal marker. The dye was introduced to the right optic tract of the rats 7 days before perfusion. Frozen coronal sections of the brains and retinal whole-mounts from al...

journal_title：Neuroscience letters

authors： Liu ZH,Jen LS

更新日期：1986-06-30 00:00:00

abstract：:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, ...

journal_title：Neuroscience letters

authors： van der Kooy D,Zito KA,Roberts DC

更新日期：1985-01-21 00:00:00

abstract：:Basal serotonin (5-HT) release, measured in the presence of imipramine, was significantly reduced in slices of hippocampus, n. accumbens and frontal cortex from rats subjected to forced swim test and chronic isolation. Only in the hippocampus, in the two animal models of depression, K-stimulated release was increased....

journal_title：Neuroscience letters

authors： Jaffe EH,De Frias V,Ibarra C

更新日期：1993-11-12 00:00:00

abstract：:Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in main...

journal_title：Neuroscience letters

authors： Xing G,Ren M,Watson WD,O'Neill JT,Verma A

更新日期：2009-04-17 00:00:00