Abstract：
:The fundamental pathological process(es) associated with schizophrenia (SZ) remain(s) uncertain, but multiple lines of evidence suggest that this condition is associated with excessive stimulation of striatal dopamine (DA) D2 receptors, deficient stimulation of medial prefrontal cortex (mPFC) D1 receptors as well as neuronal apoptosis. Unlike typical antipsychotics, stepholidine (SPD), which is isolated from the Chinese herb stephania, has D1 and D2 dual properties and regulates neuronal cell differentiation and proliferation. It is unknown, however, whether it possesses a neuroprotective property. Here, we report that SPD prevented neuronal cell death from H2O2 exposure and increased the levels of phosphorylated Akt (pAkt), a serine/threonine protein kinase. The SPD-induced neuroprotection and activation of Akt were blocked by LY294002, a PI3-K inhibitor, suggesting that the anti-apoptotic action of SPD is mediated via the PI3-K/Akt signaling pathway. Thus, as a survival or anti-apoptotic factor for neuronal cells, SPD may contribute to the therapeutic action of SPD in SZ treatment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhang L,Zhou R,Xiang Gdoi
10.1016/j.neulet.2005.04.016keywords:
subject
Has Abstractpub_date
2005-08-05 00:00:00pages
328-32issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00403-9journal_volume
383pub_type
杂志文章abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...
journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.10.056
更新日期：2006-03-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.10.042
更新日期：2015-01-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.01.022
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90484-3
更新日期：1988-06-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.09.032
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.12.005
更新日期：2004-05-06 00:00:00
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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更新日期：2009-09-22 00:00:00
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更新日期：2000-09-15 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.09.039
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00959-2
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1994-11-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.06.066
更新日期：2012-08-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-05-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.06.010
更新日期：2005-10-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-01-18 00:00:00
