Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent.

abstract：:In the present study we aimed at evaluating the prevalence and the associated clinical, neuropsychological and behavioral features of extrapyramidal symptoms in Frontotemporal Dementia (FTD) patients. Seventy-five patients fulfilling clinical criteria of FTD were consecutively enrolled. Each patient underwent clinical...

journal_title：Neuroscience letters

authors： Padovani A,Agosti C,Premi E,Bellelli G,Borroni B

更新日期：2007-07-05 00:00:00

abstract：:Our previous work has established that adenosine is toxic to chick embryonic sympathetic neurons and kills freshly plated neurons by a process of apoptosis. Although the exact mechanism remains unknown, we found that phosphorylation of adenosine was essential to the toxicity. Using markers for RNA ([3H]uridine) and pr...

journal_title：Neuroscience letters

authors： Kulkarni JS,Przywara DA,Wakade TD,Wakade AR

更新日期：1998-06-05 00:00:00

abstract：:Neuronal recording and neuroimaging studies have shown that the primary motor area (M1) not only participates in motor execution, but is also engaged during movement preparation. The purpose of the present study was to map the distribution of the preparation- and execution-related activity within the contralateral M1 ...

journal_title：Neuroscience letters

authors： Zang Y,Jia F,Weng X,Li E,Cui S,Wang Y,Hazeltine E,Ivry R

更新日期：2003-02-06 00:00:00

abstract：:Neurotrophic factors may be used to improve the growth and repair of injured peripheral nerves. In this study we determined the effectiveness of recombinant human growth hormone on peripheral nerve injury in the Wistar rat. The ulnar nerve of the rat was sectioned and its proximal and distal ends were sutured to eithe...

journal_title：Neuroscience letters

authors： Saceda J,Isla A,Santiago S,Morales C,Odene C,Hernández B,Deniz K

更新日期：2011-10-24 00:00:00

abstract：:Lead is a neurotoxicant of immense public health importance. Epidemiology studies suggest that heavy metal exposure may be associated with an increased risk of cognitive decline, yet few studies to date have assessed the effect of adult lead exposure on cognitive behavior in animal models. Here, we exposed 6-week-old ...

journal_title：Neuroscience letters

authors： Engstrom AK,Xia Z

更新日期：2017-11-20 00:00:00

abstract：:Recent findings indicated that the excitotoxicity of glutamate analogues was prevented in the mammalian nervous system by N-methyl-D-aspartate (NMDA) antagonists. The neurodegenerative effects of kainic acid, and the putative protection of MK-801 and 6,7-dinitroquinoxaline-2,3-dione (DNQX), were investigated by morpho...

journal_title：Neuroscience letters

authors： Villani L,Carraro S,Guarnieri T

更新日期：1995-06-09 00:00:00

abstract：:Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin. The functional role of PACRG is not well understood, although the gene has been associated with parkinsonian syndromes and more recently with eukaryotic cilia and flagella. We investiga...

journal_title：Neuroscience letters

authors： Wilson GR,Tan JT,Brody KM,Taylor JM,Delatycki MB,Lockhart PJ

更新日期：2009-08-21 00:00:00

abstract：:Mammalian olfactory sensory neurons (OSNs), the primary elements of the olfactory system, are located in the olfactory epithelium lining the nasal cavity. Exposed to the environment, their lifespan is short. Consequently, OSNs are regularly regenerated and several reports show that activity strongly modulates their de...

journal_title：Neuroscience letters

authors： Molinas A,Aoudé I,Soubeyre V,Tazir B,Cadiou H,Grosmaitre X

更新日期：2016-07-28 00:00:00

abstract：:Activation of microglia is a central part of the chronic inflammatory process in Alzheimer disease (AD). The monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a role in microglial migration and accumulation at sites of beta-amyloid deposition in senile plaques in the AD brain. A polymorphism in the ...

journal_title：Neuroscience letters

authors： Combarros O,Infante J,Llorca J,Berciano J

更新日期：2004-04-22 00:00:00

abstract：:To demonstrate the preference of lactate over glucose as an energy substrate in normal brain tissue under normoxic condition, the dynamic changes in glucose uptake by lactate loading were investigated in living rat brain slices using a positron autoradiography technique. Fresh rat brain slices were incubated with [18F...

journal_title：Neuroscience letters

authors： Murata T,Waki A,Omata N,Fujibayashi Y,Sadato N,Yano R,Yoshimoto M,Isaki K,Yonekura Y

更新日期：1998-06-19 00:00:00

abstract：:Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of...

journal_title：Neuroscience letters

authors： Lamb K,Bielefeldt K

更新日期：2003-01-09 00:00:00

abstract：:We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired perf...

journal_title：Neuroscience letters

authors： Nabeshima T,Ogawa S,Nishimura H,Fuji K,Kameyama T,Sasaki Y

更新日期：1991-01-14 00:00:00

abstract：:In the present study, tyrosine hydroxylase (TH; EC 1.14.16.2) cDNA was transfected into cultured fibroblasts and the production of L-3,4-dihydroxyphenylalanine (L-DOPA) was determined. Type 2 TH cDNA was transfected into fibroblasts (NRK-49F) derived from the normal rat kidney, and the expression of the TH minigene wa...

journal_title：Neuroscience letters

authors： Uchida K,Ishii A,Kaneda N,Toya S,Nagatsu T,Kohsaka S

更新日期：1990-02-16 00:00:00

abstract：:Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this...

journal_title：Neuroscience letters

authors： Jin K,Mao XO,Xie L,Khan AA,Greenberg DA

更新日期：2008-01-10 00:00:00

abstract：:Theta rhythms in the hippocampus are believed to be the "metric" relating to various behavior patterns for free roaming rats. In this study, the theta rhythms were studied while rats either walked or were passively translated by a toy car on a linear track (referred to as WALK and TRANS respectively). For the similar ...

journal_title：Neuroscience letters

authors： Xie K,Yan Y,Fang X,Gao S,Hong B

更新日期：2012-04-25 00:00:00

abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

journal_title：Neuroscience letters

authors： Choi DJ,Kwon JK,Joe EH

更新日期：2018-10-15 00:00:00

abstract：:It is known that maternal deprivation induces hippocampal damage in the developing brains. In the present study, we examined the effects of melatonin on maternal deprivation-induced hippocampal damage both during and after stress-hyporesponsive period (SHRP). Hippocampal damage was examined by cresyl violet staining a...

journal_title：Neuroscience letters

authors： Tugyan K,Uysal N,Ozdemir D,Sonmez U,Pekcetin C,Erbil G,Sonmez A

更新日期：2006-05-01 00:00:00

abstract：:Four weeks after lesion of the cortico-striatal pathway, the specific kainic acid binding was reduced by 20% in the neostriatum. It is concluded that the binding sites are most likely not located on cortico-striatal neurons. The displacement of kainic acid by some chemical indicates that the kainic acid binding site i...

journal_title：Neuroscience letters

authors： Henke H,Cuénod M

更新日期：1979-03-01 00:00:00

abstract：:In anorexia nervosa patients, body image distortion is a core and often persistent symptom, which continues to pose a risk for relapse even after weight recovery. Using functional magnetic resonance imaging (fMRI) in combination with a computer-based life image distortion technique, we stimulated female anorectic pati...

journal_title：Neuroscience letters

authors： Seeger G,Braus DF,Ruf M,Goldberger U,Schmidt MH

更新日期：2002-06-21 00:00:00

abstract：:The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age=25.9+/-10.0 years) were studied. 3D SPGR MRIs (TR=25 ms, TE=5 ms, s...

journal_title：Neuroscience letters

authors： Monkul ES,Matsuo K,Nicoletti MA,Dierschke N,Hatch JP,Dalwani M,Brambilla P,Caetano S,Sassi RB,Mallinger AG,Soares JC

更新日期：2007-12-11 00:00:00

abstract：:Nociceptin/orphanin FQ (NC) and its receptor (OP(4)) have been implicated in the regulation of various functions including nociception. [Nphe(1)]NC(1-13)NH(2) (Nphe) is a selective OP(4) antagonist which prevents the pronociceptive effects of supraspinal NC and causes per se a naloxone-insensitive antinociceptive effe...

journal_title：Neuroscience letters

authors： Di Giannuario A,Rizzi A,Pieretti S,Guerrini R,Bertorelli R,Salvadori S,Regoli D,Calo G

更新日期：2001-12-04 00:00:00

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the pretectal areas were made, we searched for the route of light information from the eyes to the circadian pacemaker, which is considered to be located in the preoptic nucleus. The entrainment of circadian activit...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H,Takeuchi H

更新日期：1995-06-16 00:00:00

abstract：:This study deals with the coordination of bilateral synchronous and asynchronous hand movements. Cooperative hand movements (e.g. opening a bottle) were shown to be coordinated by a neural coupling, reflected in the appearance of reflex responses in forearm muscles of both sides to unilateral arm nerve stimulation. Th...

journal_title：Neuroscience letters

authors： Köchli S,Scharfenberger T,Dietz V

更新日期：2020-02-16 00:00:00

abstract：:The antagonism of some benzodiazepine (Bz) actions by physostigmine was investigated in 4 Papio papio baboons. As a model of these actions, the myoclonus induced in this species by clonazepam i.m. administration was used. The baboon develops, 20-30 min after Bz i.m. injection, a non-epileptic myoclonus characterized b...

journal_title：Neuroscience letters

authors： Rektor I,Bryere P,Valin A,Silva-Barrat C,Naquet R,Menini C

更新日期：1984-11-23 00:00:00

abstract：:Pain threshold and pain tolerance of heat noxious stimuli were assessed to determine whether they are equivalent when measured at three equidistant sites of both volar forearms. Heat pain threshold and tolerance were measured in 18 healthy volunteers using a standard stimulation device consisting of a thermode. Pain t...

journal_title：Neuroscience letters

authors： Schaffner N,Wittwer A,Kut E,Folkers G,Benninger DH,Candia V

更新日期：2008-08-08 00:00:00

abstract：:Adenosine modulates hippocampal synaptic plasticity, namely long-term potentiation (LTP) and long-term depression (LTD), through activation of A1 and A2A receptors. We now report a novel role for the recently described adenosine A3 receptor in the regulation of synaptic plasticity in the CA1 area of hippocampal slices...

journal_title：Neuroscience letters

authors： Costenla AR,Lopes LV,de Mendonça A,Ribeiro JA

更新日期：2001-04-13 00:00:00

abstract：BACKGROUND/AIM:Depressive disorders are multifactorial diseases, in which cognitive impairment is one of the characteristic feature. One of the molecules that regulate of various cognitive, emotional and behavioural processes is nitric oxide (NO), synthesized from l-arginine by a family of isoformic enzymes known as ni...

journal_title：Neuroscience letters

authors： Talarowska M,Gałecki P,Maes M,Orzechowska A,Chamielec M,Bartosz G,Kowalczyk E

更新日期：2012-02-29 00:00:00

abstract：:Hyperforin is the main antidepressant component of hypericum perforatum (St. John's Wort). Using the push-pull superfusion technique we tested whether hyperforin influences extracellular concentrations of neurotransmitters in the rat locus coeruleus. Hyperforin (10 mg/kg, i.p.) not only enhanced the extracellular leve...

journal_title：Neuroscience letters

authors： Kaehler ST,Sinner C,Chatterjee SS,Philippu A

更新日期：1999-03-12 00:00:00

abstract：:Acetylcholinesterase staining was examined in the substantia innominata of 3 normal human brains. Large intensely stained neurones were seen within the region of the basal nucleus of Meynert which is believed to be the origin of the cholinergic projection to the neocortex in animals. On the basis of the acetylcholines...

journal_title：Neuroscience letters

authors： Rossor MN,Svendsen C,Hunt SP,Mountjoy CQ,Roth M,Iversen LL

更新日期：1982-02-12 00:00:00

abstract：:The idiopathic scoliosis is characterized by a three-dimensional spinal deformity involving new dynamical strategies to regulate the posture. The aim is to analyze the centre of pressure (CP) behaviour in forward stepping (FS) and lateral stepping (LS) to determine the dynamical consequences of scoliosis. Ten adolesce...

journal_title：Neuroscience letters

authors： Bruyneel AV,Chavet P,Bollini G,Allard P,Mesure S

更新日期：2008-12-12 00:00:00