Abstract:
:We have previously shown that mu-selective opioid agonists activate both an inward rectifying and a voltage-gated potassium conductance in acutely dissociated non-pyramidal neurons from rat hippocampus. We now report that the opioid-activated voltage-gated potassium conductance was blocked by the membrane permeable cAMP analogue 8-bromo-cAMP. In contrast, 8-bromo-cGMP failed to inhibit opioid activation of the voltage-gated potassium current. These results suggest that the opioid-activated potassium channel is regulated by cAMP-dependent phosphorylation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wimpey TL,Chavkin Cdoi
10.1016/0304-3940(92)90316-ykeywords:
subject
Has Abstractpub_date
1992-03-16 00:00:00pages
137-40issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90316-Yjournal_volume
137pub_type
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journal_title:Neuroscience letters
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