Abstract:
:Segments of the mouse sciatic nerve were preloaded with either d-2,3-(3)H-Aspartic acid [nonmetabolizable analog of glutamate] or l-(14)C-proline and the release of these exogenous molecules was evaluated in the fractions of the perfusate following electrical or magnetic stimulation. The electrical stimulation (10Hz, 10Am, 20s) induced an instantaneous increase in the release of both molecules, although the release of d-2,3-(3)H-Aspartic acid was much greater. Moreover, contrary to l-(14)C-proline, the release of d-2,3-(3)H-Aspartic acid was Ca(2+)-dependent. While magnetic stimulation (15mT, 0.16Hz, 30min) also induced the release of d-2,3-(3)H-Aspartic acid in a Ca(2+)-dependent way, the release of l-(14)C-proline was negligible. These results indicate that axons can release glutamate in a specific, calcium-dependent way. This release may contribute to interaxonal interactions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wieraszko A,Ahmed Zdoi
10.1016/j.neulet.2009.04.024subject
Has Abstractpub_date
2009-07-10 00:00:00pages
19-22issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00488-1journal_volume
458pub_type
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