Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit.

abstract：:The pharmacology of the metabotropic glutamate receptor (mGluR)-mediated potentiation of N-methyl-D-aspartate (NMDA)-evoked depolarisations in the CA1 region of rat hippocampal slices was investigated using an extracellular grease-gap method. The group I and II mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxyli...

journal_title：Neuroscience letters

authors： Fitzjohn SM,Irving AJ,Palmer MJ,Harvey J,Lodge D,Collingridge GL

更新日期：1996-01-26 00:00:00

abstract：:Ibotenic acid was injected in the lateral geniculate nucleus of cats to investigate the suitability of the technique in studies involving anterograde degeneration in the thalamo-cortical pathway when it is important not to damage fibres of passage at the lesion site. Small injections cause localized degeneration of ne...

journal_title：Neuroscience letters

authors： Garey LJ,Hornung JP

更新日期：1980-09-01 00:00:00

abstract：:In the experiments described in the present report, we evaluated the effects of ethanol on the activity of GABAA receptors of cerebellar granule cells in culture. Only very high ethanol concentrations (100-300 mM) showed a clear and significant stimulatory effect on the activity of such receptors. This result was unex...

journal_title：Neuroscience letters

authors： Casagrande S,Cupello A,Pellistri F,Robello M

更新日期：2007-03-13 00:00:00

abstract：:Current theories of orbitofrontal cortex (OFC) function suggest that this region should participate in the generation of error-related signals associated with the outcomes of actions. We investigated the impact of lesions to OFC on the error-related negativity (ERN), an electrophysiological marker of performance monit...

journal_title：Neuroscience letters

authors： Turken AU,Swick D

更新日期：2008-08-15 00:00:00

abstract：:Glycinergic inhibitory neurotransmission plays a pivotal role in the development of neuropathic pain. The glycine concentration in the synaptic cleft is controlled by the glycine transporters GlyT1 and GlyT2. GlyT1 is expressed throughout the central nervous system, while GlyT2 is exclusively located in glycinergic ne...

journal_title：Neuroscience letters

authors： Schlösser L,Barthel F,Brandenburger T,Neumann E,Bauer I,Eulenburg V,Werdehausen R,Hermanns H

更新日期：2015-07-23 00:00:00

abstract：:The action of some cholinergic drugs has been studied on the field potentials evoked by orthodromic stimulation of the lateral olfactory tract (LOT) in guinea-pig olfactory cortex slices maintained in vitro. A reversible depression of the electrically evoked surface-negative field potential (N-wave) was seen following...

journal_title：Neuroscience letters

authors： Williams SH,Constanti A,Brown DA

更新日期：1985-05-23 00:00:00

abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...

journal_title：Neuroscience letters

authors： Yang Z,Zhang Y,Wu G

更新日期：2001-06-22 00:00:00

abstract：:We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...

journal_title：Neuroscience letters

authors： Cobcroft M,Vaccaro T,Mitrofanis J

更新日期：1989-08-14 00:00:00

abstract：:Little is known about the effect of wnt-3a on motor nerve function and its specific molecular mechanisms after spinal cord injury (SCI). This study demonstrates that the downregulated expression levels of caspases-3, caspases-9 and chondroitin sulfate proteoglycan (CSPG) proteins and number of proportion of transferas...

journal_title：Neuroscience letters

authors： Gao K,Niu J,Dang X

更新日期：2020-10-15 00:00:00

abstract：:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high ...

journal_title：Neuroscience letters

authors： Helbecque N,Cottel D,Codron V,Berr C,Amouyel P

更新日期：2004-03-18 00:00:00

abstract：:The formation of the beta pleated configuration of the amyloid peptide fragment 25-35 in aqueous solution, has been studied using thioflavin-T fluorescence as an indicator of such folding. Both phosphate and adenosine triphosphate (ATP) enhance the formation of aggregated beta-sheets. This phosphate-induced aggregatio...

journal_title：Neuroscience letters

authors： Bondy SC,Truong A

更新日期：1999-05-21 00:00:00

abstract：:The expression of five muscarinic receptor mRNAs (m1, m2, m3, m4, m5) was examined in neostriatum, hippocampus and frontal cortex of 3, 18, and 33 month old rats. Transcripts for ml (3.0 kb), m2 (6.2 kb), m3 (4.5 kb) and m4 (3.3 kb) were detected in all brain regions studied. A 6.0 kb transcript for the m5 muscarinic ...

journal_title：Neuroscience letters

authors： Lee HJ,Clagett-Dame M,Heideman W,Weiler MS

更新日期：1994-06-20 00:00:00

abstract：:Whole-cell patch clamp recordings were obtained during motor activity from electrically identified motoneurons within the spinal cord of the chick embryo maintained in vitro. Most recordings were performed on E11-E13 motoneurons although it was also possible to record from younger cells (E7-E9). Voltage clamp recordin...

journal_title：Neuroscience letters

authors： Sernagor E,O'Donovan MJ

更新日期：1991-07-22 00:00:00

abstract：:Recombinant gamma-aminobutyric acid (GABA(A)) receptor channels containing alpha1beta2gamma2-subunits were transiently expressed in HEK293 cells. Modulation by diazepam (DZ) was investigated using the patch-clamp technique with a device for ultra-fast solution exchange. GABA activated Cl(-)-currents were potentiated w...

journal_title：Neuroscience letters

authors： Krampfl K,Lepier A,Jahn K,Franke C,Bufler J

更新日期：1998-11-13 00:00:00

abstract：:Stress is a major risk factor in drug addiction development and relapse. Virtually all drugs of abuse act by increasing extracellular dopamine levels in the striatum. To gain an understanding of the interaction between stress and drug exposure, we studied the effects of concomitant chronic nicotine and chronic stress ...

journal_title：Neuroscience letters

authors： Salas R,De Biasi M

更新日期：2008-07-25 00:00:00

abstract：:Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (...

journal_title：Neuroscience letters

authors： Henke H

更新日期：1979-10-01 00:00:00

abstract：:Use of intravenous guanethidine for the treatment of complex regional pain syndrome type I is of variable efficacy. Guanethidine injection is painful, so local anaesthetic is co-administered. We hypothesize that local anaesthetic inhibits uptake of guanethidine and hence reduces its efficacy. In this study we have exa...

journal_title：Neuroscience letters

authors： Joyce PI,Atcheson R,Marcus RJ,Heffernan AM,Rowbotham DJ,Lambert DG

更新日期：2001-06-15 00:00:00

abstract：:The factors determining the large variation seen in human corpus callosum (CC) morphology are as yet unknown. In this study heritability of CC size was assessed by comparing the concordance of CC midsagittal area in 14 monozygotic and 12 dizygotic twin pairs with a mean age of 27 years, using magnetic resonance imagin...

journal_title：Neuroscience letters

authors： Scamvougeras A,Kigar DL,Jones D,Weinberger DR,Witelson SF

更新日期：2003-02-27 00:00:00

abstract：:We used whole-head magnetoencephalography to investigate cortical activity during two oromotor activities foundational to speech production. 13 adults performed mouth opening and phoneme (/pa/) production tasks to a visual cue. Jaw movements were tracked with an ultrasound-emitting device. Trials were time-locked to b...

journal_title：Neuroscience letters

authors： Memarian N,Ferrari P,Macdonald MJ,Cheyne D,De Nil LF,Pang EW

更新日期：2012-10-03 00:00:00

abstract：:Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAChR silent agonist N...

journal_title：Neuroscience letters

authors： Papke RL,Peng C,Kumar A,Stokes C

更新日期：2018-06-11 00:00:00

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:Gangliosides isolated from the brain of patients with Creutzfelt-Jakob (C-J) disease were analyzed. The ganglioside current was abnormally low, and the percentage distributions of individual gangliosides and the long-chain base compositions were abnormal. The C20-sphingosine contents of all the ganglioside fractions w...

journal_title：Neuroscience letters

authors： Tamai Y,Ohtani Y,Miura S,Narita Y,Iwata T,Kaiya H,Namba M

更新日期：1979-01-01 00:00:00

abstract：:The size and somatotopic distribution of corneal afferent neurons in the guinea pig trigeminal ganglion were determined using a retrograde axonal tracing technique. Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was applied to the central cornea of the guinea pig and the animals were perfusion-fixed 48 h later...

journal_title：Neuroscience letters

authors： Keller JT,Bubel HC,Wander AH,Tierney BE

更新日期：1991-01-02 00:00:00

abstract：:We reported previously that administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (ODHPC), a kind of phosphatidylcholine, enhanced discriminatory shock avoidance learning in rats. Since long-term potentiation (LTP) of the hippocampus has been suggested to be a physiological substrate of some form...

journal_title：Neuroscience letters

authors： Izaki Y,Hashimoto M,Arita J

更新日期：1999-01-29 00:00:00

abstract：:Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventrolateral medulla (RVL), two-color immunoperoxidase staining was employed to demonstrate contiguity between PHA-L-immunoreactive (PHA-LI) varicose fibers and boutons and brainstem monoaminergic cells. Black-staine...

journal_title：Neuroscience letters

authors： Nicholas AP,Hancock MB

更新日期：1991-01-14 00:00:00

abstract：:A two pulse technique was used to study the decay of mechanical activation in TTX poisoned mouse extensor digitorum longus (EDL) and soleus muscle fibres. A two microelectrode point voltage clamp technique was used with visual endpoint determination of the threshold potential for activation. The excitatory effect of a...

journal_title：Neuroscience letters

authors： Dulhunty AF

更新日期：1979-10-01 00:00:00

abstract：:The uptake of 2-deoxy-[14C]glucose (2-DG) by motor neurons in adult rat hypoglossal nuclei was studied 3 days after subepineural injection of 'crude' soluble protein extracts from intact and injured peripheral nerves into normal hypoglossal nerves. Injured nerve extracts were obtained from 'proximal' and 'distal' segm...

journal_title：Neuroscience letters

authors： Singer PA,Mehler S,Fernandez HL

更新日期：1988-01-22 00:00:00

abstract：:Single electrode voltage-clamp recording from CA3 neurons in guinea pig hippocampal slices was applied to study effects of a new GABAB antagonist, CGP 55845A, on (-)baclofen (IBac)- or gamma-aminobutyric acid (IGABA)-induced potassium (K)-currents and on inhibitory postsynaptic K-currents (K-IPSCs) recorded in the pre...

journal_title：Neuroscience letters

authors： Jarolimek W,Demmelhuber J,Bijak M,Misgeld U

更新日期：1993-05-14 00:00:00

abstract：:Normal rats tend to respond to a sudden burst of noise or flash of light with slightly less startle when they are engaged in active behaviour at the time of presentation. This effect is vastly more pronounced in animals with lesions of the superior colliculus. These results are taken as support for a theory implicatin...

journal_title：Neuroscience letters

authors： Goodale MA,Milner AD,Rose JE

更新日期：1975-12-01 00:00:00

abstract：:A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated ...

journal_title：Neuroscience letters

authors： Crawley JN,Patel J,Marangos PJ

更新日期：1983-04-11 00:00:00