Abstract:
:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly improve neuronal differentiation rate of rat FT-NPCs in vitro. We investigated the influence of EF strength on rat FT-NPCs differentiation. By adding reasonable strength of EF to FT-NPCs, our data shows a significant increase in neuronal differentiation rate. The present innovation provides a novel method of directional differentiation and efficient production of neurons from FT-NPCs in vitro. This improved approach for inducing neuronal differentiation can be applied to future research on autoplastic transplantation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XTdoi
10.1016/j.neulet.2017.05.001subject
Has Abstractpub_date
2017-06-09 00:00:00pages
109-115eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30379-8journal_volume
651pub_type
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