Electric field stimulation induced neuronal differentiation of filum terminale derived neural progenitor cells.

Abstract:

:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly improve neuronal differentiation rate of rat FT-NPCs in vitro. We investigated the influence of EF strength on rat FT-NPCs differentiation. By adding reasonable strength of EF to FT-NPCs, our data shows a significant increase in neuronal differentiation rate. The present innovation provides a novel method of directional differentiation and efficient production of neurons from FT-NPCs in vitro. This improved approach for inducing neuronal differentiation can be applied to future research on autoplastic transplantation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

doi

10.1016/j.neulet.2017.05.001

subject

Has Abstract

pub_date

2017-06-09 00:00:00

pages

109-115

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(17)30379-8

journal_volume

651

pub_type

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