Localization of dystrophin in the Purkinje cells of normal mice.

abstract：:Prevention of beta-amyloid (Abeta) production, aggregation and formation of Abeta deposits is a key pharmacological target in Alzheimer's disease. The passage of Abeta-binding compounds through the blood-brain barrier is often hampered for free ligands, whereas it is enhanced by drug encapsulation in nanoparticles. He...

journal_title：Neuroscience letters

authors： Härtig W,Paulke BR,Varga C,Seeger J,Harkany T,Kacza J

更新日期：2003-02-27 00:00:00

abstract：:Decreased dopamine (DA) release in the hippocampus may be caused by dysfunctional mastication, although the mechanisms involved remain unclear. The present study examined the effects of soft- and hard-food diets on oxidative stress in the brain, and the relationship between these effects and hippocampal DA levels. The...

journal_title：Neuroscience letters

authors： Yoshino F,Yoshida A,Hori N,Ono Y,Kimoto K,Onozuka M,Lee MC

更新日期：2012-02-02 00:00:00

abstract：:Central administration of C-type natriuretic peptide (CNP) affects various neuroendocrine systems. In the present study, we examined whether CNP acts directly on arginine-vasopressin (AVP) secretion from rat supraoptic nucleus (SON) neurons, using acute dissociated cell preparations. CNP inhibited the basal secretion ...

journal_title：Neuroscience letters

authors： Yamamoto S,Morimoto I,Yanagihara N,Kangawa K,Inenaga K,Eto S,Yamashita H

更新日期：1997-06-27 00:00:00

abstract：:Influences of a submaximal endurance test in the right first dorsal interosseus on force and fatigue-related parameters of activating the contralateral muscle were studied. The test consisted of a 30% maximum voluntary contraction (MVC), regularly interrupted by maximal contractions and brief rest periods. Despite the...

journal_title：Neuroscience letters

authors： Zijdewind I,Zwarts MJ,Kernell D

更新日期：1998-08-28 00:00:00

abstract：:The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult,...

journal_title：Neuroscience letters

authors： Onodera H,Sato G,Kogure K

更新日期：1986-07-24 00:00:00

abstract：:Miyoshi myopathy (MM) is an autosomal recessive distal muscular dystrophy caused by mutations in the dysferlin gene (DYSF), a 150-kb gene on chromosome 2p13 that contains 55 coding exons. Many patients with MM harbour mutations in the DYSF gene, and most of these mutations are inherited from the patients' parents. Rec...

journal_title：Neuroscience letters

authors： Hu YY,Lian YJ,Xu HL,Zheng YK,Li CF,Zhang JW,Yan SP

更新日期：2018-01-18 00:00:00

abstract：:Psychotic symptoms are common in individuals with Alzheimer's disease (AD), and define a phenotype associated with more rapid cognitive and functional decline. Evidence suggests that psychotic symptoms may be influenced by genetic factors, and recent studies in schizophrenia, bipolar affective disorder (BPAD) and Alzh...

journal_title：Neuroscience letters

authors： Sims R,Hollingworth P,Moskvina V,Dowzell K,O'Donovan MC,Powell J,Lovestone S,Brayne C,Rubinsztein D,Owen MJ,Williams J,Abraham R

更新日期：2009-09-11 00:00:00

abstract：:Spontaneous gasps were recorded in pentobarbitone-anesthetized adult cats. Mean interval between gasps in 11 cats with their buffer nerves intact was of 65 sec; it was significantly prolonged to 174 sec after unilateral carotid neurotomy and to 403 sec after bilateral carotid neurotomy. Additional sectioning of both a...

journal_title：Neuroscience letters

authors： Zuazo A,Zapata P

更新日期：1980-01-01 00:00:00

abstract：:Local warming or cooling of the preoptic and anterior hypothalamus (PO/AH) areas evokes various thermoregulatory responses in mammals. We have hypothesized that warm- and cold-sensitive neurons recorded in the PO/AH are multiple thermostats that regulate the core temperature against heat and cold, respectively. Howeve...

journal_title：Neuroscience letters

authors： Abe J,Okazawa M,Adachi R,Matsumura K,Kobayashi S

更新日期：2003-05-15 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is a clinically complex and multifactorial psychiatric disorder of inattention, hyperactivity and impulsivity. Family, twin and adoption studies suggest a genetic influence in the etiology of ADHD. Two variable number of tandem repeats (VNTR) polymorphic systems have bee...

journal_title：Neuroscience letters

authors： Gabriela ML,John DG,Magdalena BV,Ariadna GS,Francisco de LP,Liz SM,Lino PC,Josefina RG,Ernesto RZ,Carlos CF

更新日期：2009-02-27 00:00:00

abstract：:Reflex micturition was evoked in both non-immobilized (n = 5) and immobilized (n = 5) decerebrate cats by filling the bladder with physiological saline. Intracellular recordings were made from pudendal motoneurons (PU-MNs; n = 14) throughout the periods of before, during and after reflex micturition. The changes in th...

journal_title：Neuroscience letters

authors： Shimoda N,Takakusaki K,Nishizawa O,Tsuchida S,Mori S

更新日期：1992-02-03 00:00:00

abstract：:The goal of the present study was to explore the relation between speed-accuracy trade-off phenomena and action kinematics in the case of pointing under isometric conditions. Increasing task difficulty resulted in a linear increase in movement time (as predicted by Fitts' law) and in systematic changes in the spatio-t...

journal_title：Neuroscience letters

authors： Billon M,Bootsma RJ,Mottet D

更新日期：2000-05-26 00:00:00

abstract：:Purkinje cell degeneration (pcd) mutant mice lose cerebellar Purkinje cells. It was found that pcd mice, contrary to normal mice, did not alternate spontaneously at any of 3 inter-trial intervals (15 s, 3 or 6 min). Deficits in spontaneous alternation are typical of animals with brain damage in areas important in spat...

journal_title：Neuroscience letters

authors： Lalonde R,Manseau M,Botez MI

更新日期：1987-10-05 00:00:00

abstract：:The binding of radioiodinated omega-conotoxin GVIA, a probable Ca channel antagonist, to synaptic plasma membranes of rat brain was examined. Two kinds of specific binding sites were found with apparent dissociation constants of 10 pM and 0.5 nM and maximum binding capacities of 0.5 and 3.4 pmol/mg prot., respectively...

journal_title：Neuroscience letters

authors： Abe T,Koyano K,Saisu H,Nishiuchi Y,Sakakibara S

更新日期：1986-11-11 00:00:00

abstract：:This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. Rats were tested for aversion to the saccharin as measured by flavor consumption and orofacial reactions in the taste reactivity (TR) test. It was found that intraperitoneal...

journal_title：Neuroscience letters

authors： Soto A,Gasalla P,Begega A,López M

更新日期：2017-04-24 00:00:00

abstract：:Pharmacogenetic studies assessing the role of 5-HT(2A) receptor gene in antipsychotic efficacy yielded conflicting data. Phenotypical heterogeneity of schizophrenia might explain such discrepancies. For example, negative symptoms are known to reflect severity of illness and to restrain therapeutic response. On this ba...

journal_title：Neuroscience letters

authors： Hamdani N,Bonnière M,Adès J,Hamon M,Boni C,Gorwood P

更新日期：2005-03-22 00:00:00

abstract：:The Amphibalanus amphitrite barnacle is a sessile marine crustacean and a major constituent of benthic as well as intertidal communities. A. amphitrite is also an important component of biofouling on artificial substrates. The role of nitric oxide (NO) was recently observed in the settlement of this species. In this w...

journal_title：Neuroscience letters

authors： Gallus L,Ferrando S,Gambardella C,Faimali M,Piazza V,Masini MA

更新日期：2013-10-25 00:00:00

abstract：:We examined the effects of chronic in vivo antipsychotic drug treatments on G protein function and regulation. Mice were treated with typical antipsychotic haloperidol (6 mg/kg per day) and atypical agent olanzapine (20 mg/kg per day) for 14 days via mini-osmotic pumps. G protein-activated adenylyl cyclase activity in...

journal_title：Neuroscience letters

authors： Kaplan GB,Leite-Morris KA,Keith DJ

更新日期：1999-10-08 00:00:00

abstract：:The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats. Age-matched male Wistar rats were divided into four groups; group I: normal control rats; group II: 6-week fructose-fed rats (FR); group III: 9-week FR; and group IV...

journal_title：Neuroscience letters

authors： Cheng JT,Tong YC

更新日期：2008-08-15 00:00:00

abstract：:Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area. This protein has been reported to interact specifically with the C-termini of AMPA-selective glutamate receptor channel subunits, GluRalpha2 and GluRalpha3 through i...

journal_title：Neuroscience letters

authors： Yamazaki M,Fukaya M,Abe M,Ikeno K,Kakizaki T,Watanabe M,Sakimura K

更新日期：2001-05-18 00:00:00

abstract：:Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned. We immunohistochemically examined the bra...

journal_title：Neuroscience letters

authors： Mori F,Tanji K,Odagiri S,Toyoshima Y,Yoshida M,Kakita A,Takahashi H,Wakabayashi K

更新日期：2012-08-01 00:00:00

abstract：:The act of tasting is the product of inseparable integrative behavior consisting of multi-sensory processing and orolingual motor coordination. Often tasting-induced brain activity is looked at in a reductionist manner as a set of isolated components. However, brain activity as a whole during tasting may not simply be...

journal_title：Neuroscience letters

authors： Okamoto M,Dan H,Clowney L,Yamaguchi Y,Dan I

更新日期：2009-02-20 00:00:00

abstract：:Songbirds and humans use auditory feedback to acquire and maintain their vocalizations. The Bengalese finch (Lonchura striata domestica) is a songbird species that rapidly modifies its vocal output to adhere to an internal song memory. In this species, the left side of the bipartite vocal organ is specialized for prod...

journal_title：Neuroscience letters

authors： Urbano CM,Peterson JR,Cooper BG

更新日期：2013-02-08 00:00:00

abstract：:Glioblastoma is the most common astrocytic brain tumor in humans. Current therapies for this malignancy are mostly ineffective. Photodynamic therapy (PDT), an exciting treatment strategy based on activation of a photosensitizer, has not yet been extensively explored for treating glioblastoma. We used 5-aminolevulinic ...

journal_title：Neuroscience letters

authors： Karmakar S,Banik NL,Patel SJ,Ray SK

更新日期：2007-03-30 00:00:00

abstract：:It is believed that subjects with high trait anxiety levels tend to present state anxiety reactions with greater intensity than individuals with low trait anxiety levels. In order to verify if this premise is valid for animal models of anxiety, the present work investigated the possible correlation between two behavio...

journal_title：Neuroscience letters

authors： Goes TC,Antunes FD,Teixeira-Silva F

更新日期：2009-02-06 00:00:00

abstract：:Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline response...

journal_title：Neuroscience letters

authors： Stone TW,Taylor DA

更新日期：1979-01-01 00:00:00

abstract：:Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-s...

journal_title：Neuroscience letters

authors： Karhula T,Soinila S,Lakomy M,Majewski M,Kaleczyk J,Häppölä O

更新日期：1995-07-14 00:00:00

abstract：:Wild-type neuronal calcium-binding protein VILIP (visinin-like protein), and a myristoylation mutant of VILIP which lacks the consensus sequence for N-terminal myristoylation, have been stably transfected in PC12 cells. Immunocytochemical studies of VILIP-transfected PC12 cells have revealed the wild-type VILIP is str...

journal_title：Neuroscience letters

authors： Spilker C,Gundelfinger ED,Braunewell KH

更新日期：1997-04-04 00:00:00

abstract：:In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

journal_title：Neuroscience letters

authors： Kothbauer K,Schmid UD,Liechti S,Rösler KM

更新日期：1993-05-14 00:00:00

abstract：:The optic nerve (ON) in adult rats was transected intraorbitally followed by retrograde labelling of retinal ganglion cells (RGCs) with fluorescence dye (DiI). A two phase reduction of axotomized RGCs was represented in the retina until 15 days after ON transection. The critical period of RGC loss is around 7 days aft...

journal_title：Neuroscience letters

authors： Takano M,Horie H

更新日期：1994-07-04 00:00:00