Abstract:
:The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult, pyramidal cells and L-glutamate binding sites in the CA1 region ipsilateral to the KA injection were preserved in spite of neuronal necrosis and a significant decrease in L-glutamate receptor density in the contralateral CA1 region, indicating the critical role of Schaffer collaterals in delayed neuronal death.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Onodera H,Sato G,Kogure Kdoi
10.1016/0304-3940(86)90136-9subject
Has Abstractpub_date
1986-07-24 00:00:00pages
169-74issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90136-9journal_volume
68pub_type
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