Abstract：
:It has long been known that primary neurons in the brain and spinal cord exhibit very distinctive dendritic structures. However, it remains unclear whether dendritic processing for signal propagation and channel activation over dendrites is a function of the cell type-specific dendritic structure. By applying an extended analysis of signal attenuation for the physiological distributions of synaptic inputs and active channels on dendritic branches, we first demonstrate that regardless of their specific structure, all anatomically reconstructed models of primary neurons display a similar pattern of directional signal attenuation and locational channel activation over their dendrites. Then, using a novel modeling approach that allows direct comparison of the anatomically reconstructed primary neurons with their reduced models that exclusively retain anatomical dendritic signaling without being associated with structural specificity, we show that the reduced model can accurately predict dendritic excitability of the anatomical model in both passive and active mode. These results indicate that the directional signaling, locational excitability and their relationship are foundational features of dendritic processing that are independent of the cell type-specific structure across primary neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kim H,Heckman CJdoi
10.1016/j.neulet.2015.10.017subject
Has Abstractpub_date
2015-11-16 00:00:00pages
203-9eissn
0304-3940issn
1872-7972pii
S0304-3940(15)30180-4journal_volume
609pub_type
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.11.037
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2013.01.011
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.08.044
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pub_type： 杂志文章
doi：10.1016/j.neulet.2004.05.117
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00489-9
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：2004-05-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.04.004
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.03.082
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pub_type： 杂志文章
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