Apolipoprotein E allele epsilon 4 is linked to increased deposition of the amyloid beta-peptide (A-beta) in cases with or without Alzheimer's disease.

abstract：:Pontine parabrachial neurons have been suggested to play a regulatory role in both respiratory and sleep cycle control. Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observ...

journal_title：Neuroscience letters

authors： Gilbert KA,Lydic R

更新日期：1990-12-11 00:00:00

abstract：:Whole-cell patch-clamp recordings (WCR) were made from sympathetic preganglionic neurons (SPN) in neonate rat spinal cord slices. SPN were identified histologically by filling them with the fluorescent dye Lucifer Yellow contained within the patch pipette solution. Current clamp recordings were obtained from SPN with ...

journal_title：Neuroscience letters

authors： Pickering AE,Spanswick D,Logan SD

更新日期：1991-09-16 00:00:00

abstract：INTRODUCTION:The saccadic paradigm has been used to investigate specific cortical networks involving attention. The behavioral and electrophysiological investigations of the SEM contribute significantly to the understanding of attentive patterns presented of neurological and psychiatric disorders and sports performance...

journal_title：Neuroscience letters

authors： Bittencourt J,Machado S,Teixeira S,Schlee G,Salles JI,Budde H,Basile LF,Nardi AE,Cagy M,Piedade R,Sack AT,Velasques B,Ribeiro P

更新日期：2012-08-15 00:00:00

abstract：:The nucleus raphe magnus belongs to the thermoafferent system. Following iontophoretic choleratoxin b injections in its rostral part, a substantial to large number of anterogradely labeled varicose fibres were observed in the medial and lateral preoptic areas, the bed nucleus, the substantia innominata, the ventral pa...

journal_title：Neuroscience letters

authors： Hermann DM,Luppi PH,Peyron C,Hinckel P,Jouvet M

更新日期：1996-10-04 00:00:00

abstract：:Serotonin (5-HT) immunocytochemistry, was performed on the whole dissected nervous system of the blowfly. Employing the peroxidase-antiperoxidase technique and osmium postfixation, it was possible to examine 5-HT-immunoreactive neuronal elements first light microscopically in 25 microns sections, and, after re-embeddi...

journal_title：Neuroscience letters

authors： Nässel DR,Elekes K

更新日期：1984-07-27 00:00:00

abstract：:Using the gerbil model of post-ischemic neuron death in the hippocampal CA1 region, it was recently shown that there is a strong down-regulation of voltage-gated Ca2+ influx in neurons examined at 2 days after the ischemic insult (Connor, J.A., Razani-Boroujerdi, S., Greenwood, A.C., Cormier, R.J., Petrozzino, J.J. an...

journal_title：Neuroscience letters

authors： Shuttleworth CW,Greenwood AC,Connor JA

更新日期：2000-06-02 00:00:00

abstract：:We examined the distribution of ferric ion-ferrocyanide stain (a marker for excitable regions of myelinated fibers) in the lead-induced demyelinating neuropathy of the rat. By electron microscopy, we found that paranodal degeneration resulted in spreading of the reaction product from nodal to internodal axolemma. Duri...

journal_title：Neuroscience letters

authors： Coria F,Silos I,Fernandez R,Monton F,Lafarga M

更新日期：1985-08-05 00:00:00

abstract：:The most current human-based studies in which brain-derived neurotrophic factor (BDNF) levels in the peripheral blood system are analyzed use it as an indicator that represents BDNF levels in the CNS. However, whether circulating BDNF (serum and plasma) is positively or inversely associated with cardiorespiratory fitn...

journal_title：Neuroscience letters

authors： Cho HC,Kim J,Kim S,Son YH,Lee N,Jung SH

更新日期：2012-06-21 00:00:00

abstract：:Functional MRI studies have revealed that the brain activity in the anterior temporal cortex during memory retrieval increases over months after memory encoding. Behavioral evidence has demonstrated that long-term memory can sometimes be consolidated more rapidly in one or two days. In the present functional MRI study...

journal_title：Neuroscience letters

authors： Jimura K,Hirose S,Wada H,Yoshizawa Y,Imai Y,Akahane M,Machida T,Shirouzu I,Koike Y,Konishi S

更新日期：2016-08-03 00:00:00

abstract：:Loss of balance and increased fall risk is a common problem associated with aging. Changes in vestibular function occur with aging but the contribution of reduced vestibular otolith function to fall risk remains unknown. We examined a population of 151 healthy individuals (aged 21-93) for both balance (sway measures) ...

journal_title：Neuroscience letters

authors： Serrador JM,Lipsitz LA,Gopalakrishnan GS,Black FO,Wood SJ

更新日期：2009-11-06 00:00:00

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the preoptic nucleus (PON) were made, we searched for the location of the circadian pacemaker in the hypothalamus. The characteristic rhythms were lost in animals lacking the anterior part of the hypothalamus, which...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H

更新日期：1993-12-24 00:00:00

abstract：:The nucleus of the basal optic root (nBOR) is involved in the generation of the optokinetic response. Previous studies showed that most nBOR neurons exhibit direction-selectivity in response to largefield motion. We investigated the responses of pigeon nBOR neurons to drifting sine wave gratings of varying spatial and...

journal_title：Neuroscience letters

authors： Crowder NA,W Wylie DR

更新日期：2001-05-25 00:00:00

abstract：:HS-142-1 is a novel non-peptide antagonist for atrial natriuretic peptide (ANP) receptor. The effect of HS-142-1 on the cyclic GMP production elicited by natriuretic peptides in neuronal cell lines, PC12 and NG108-15 was examined. Natriuretic peptides such as ANP, brain natriuretic peptide (BNP), and C-type natriureti...

journal_title：Neuroscience letters

authors： Toki S,Morishita Y,Sano T,Matsuda Y

更新日期：1992-01-20 00:00:00

abstract：:Copulation was induced in pairs of Aplysia fasciata by adding to the environment a homogenate of the distal portion of the large hermaphroditic duct. Similar effects were not observed in response to an abdominal ganglion homogenate. The data suggest that the duct may secrete a pheromone initiating copulation in Aplysi...

journal_title：Neuroscience letters

authors： Susswein AJ,Benny M

更新日期：1985-09-06 00:00:00

abstract：:We investigated the conduction velocity of motor and autonomic nerves, motor nerve to foot interosseous muscle and cervical vagus and sympathetic nerve, in streptozotocin diabetic rats (1-3 months duration of diabetes) and compared it with that of age-matched controls. In diabetic rats, the motor nerve conduction velo...

journal_title：Neuroscience letters

authors： Yamazaki Y,Karakida T,Homma S

更新日期：1990-05-18 00:00:00

abstract：:The functional interaction in the spinal cord between substance P and excitatory amino acid agonists was investigated. Behavioural responses were scored in mice after intrathecal administration of excitatory amino acid agonists and substance P, given separately or in combination. A strong potentiation of the effect wa...

journal_title：Neuroscience letters

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1991-11-25 00:00:00

abstract：:8-Hydroxy-2-[di-n-propylamino]-tetralin) (8-OH-DPAT), a 5-HT1A/7 receptor agonist, has a chronobiological effect on the circadian system. To identify how the 8-OH-DPAT exerts this effect, we specifically destroyed the serotonergic (5-HT) fibres connecting the median raphe nuclei (RN) to the suprachiasmatic nuclei (SCN...

journal_title：Neuroscience letters

authors： Schuhler S,Saboureau M,Pitrosky B,Pévet P

更新日期：1998-10-30 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:The potassium-chloride cotransporter 2 (KCC2)-dependent intracellular chloride level determines whether neurons respond to GABA and/or glycine by depolarization or hyperpolarization. However, still unknown is the role of KCC2-dependent chloride homeostasis in regulating the spontaneous activity of neuronal circuits vi...

journal_title：Neuroscience letters

authors： Wang W,Xu TL

更新日期：2006-10-02 00:00:00

abstract：:Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum i...

journal_title：Neuroscience letters

authors： Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Y

更新日期：2012-11-21 00:00:00

abstract：:The convulsive agent pentylenetetrazol (PTZ) antagonized gamma-aminobutyric acid (GABA)-induced membrane currents on RNA-injected Xenopus oocytes with both extra- and intracellular applications. With extracellular administration PTZ enters the cell within a few minutes and reaches concentrations in the millimolar rang...

journal_title：Neuroscience letters

authors： Bloms-Funke P,Madeja M,Musshoff U,Speckmann EJ

更新日期：1996-02-23 00:00:00

abstract：:Almost all mechanoreceptive neurons in the cortical taste area (CTA) of the rat had receptive fields (RFs) in the oral cavity, except for a few neurons at the border with the primary somatosensory area that had RFs on the contralateral rhinarium or upper lip. About one-third of the mechanoreceptive neurons with RFs in...

journal_title：Neuroscience letters

authors： Ogawa H,Wang XD

更新日期：2002-04-05 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:The present magnetoencephalographic study was conducted in order to assess the accuracy of dipole localizations for the movement-evoked field component 1 (MEF 1). Three male subjects were requested to perform self-paced flexions of their index finger and thumb in repeated sessions of 60 trials while the neuromagnetic ...

journal_title：Neuroscience letters

authors： Rosburg T,Weiss T,Haueisen J,Nowak H,Sauer H

更新日期：1996-08-30 00:00:00

abstract：:A new non-N-methyl-D-aspartate (non-NMDA) glutamate receptor antagonist, GYKI 52466, was tested on L-glutamate (Glu)-, kainate (KAI)- and NMDA-induced responses in vivo, using both extracellular recording of antidromic field potentials and intracellular recording from rat abducens motoneurones. Intravenous (5-10 mg/kg...

journal_title：Neuroscience letters

authors： Ouardouz M,Durand J

更新日期：1991-04-15 00:00:00

abstract：:Because there are sex differences in feeding-related behavior and orexin neurons are involved in feeding, we looked for a possible sex difference in the response of orexin neurons in the lateral hypothalamic area to fasting, using the phosphorylated cyclic AMP response element-binding protein (pCREB) as a marker of ne...

journal_title：Neuroscience letters

authors： Funabashi T,Hagiwara H,Mogi K,Mitsushima D,Shinohara K,Kimura F

更新日期：2009-09-29 00:00:00

abstract：:Fractalkine is a CX3C chemonkine that appears to be a neuron-to-microglia signal molecule in the central nervous system. We studied the expression of fractalkine in normal human astrocytes in culture, by using semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. We f...

journal_title：Neuroscience letters

authors： Yoshida H,Imaizumi T,Fujimoto K,Matsuo N,Kimura K,Cui X,Matsumiya T,Tanji K,Shibata T,Tamo W,Kumagai M,Satoh K

更新日期：2001-05-04 00:00:00

abstract：:Erythropoietin (EPO) has recently been shown to have a neuroprotective effect in animal models of traumatic brain injury (TBI). However, the precise mechanisms remain unclear. Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI. We, therefore, tried to analyze how reco...

journal_title：Neuroscience letters

authors： Chen G,Shi JX,Hang CH,Xie W,Liu J,Liu X

更新日期：2007-10-02 00:00:00

abstract：:We have compared changes in mRNA of three genes, zif268, raf B, and syntaxin 1 B, following the unilateral induction of long-term potentiation (LTP) in rats previously trained in a water maze, and in behaviourally naive animals. mRNA of all three genes was enhanced in the potentiated dentate gyrus of naive animals 3 h...

journal_title：Neuroscience letters

authors： Richter-Levin G,Thomas KL,Hunt SP,Bliss TV

更新日期：1998-07-17 00:00:00

abstract：:Accumulating evidence suggests that abnormal fatty acid composition is related to the development of Alzheimer's disease (AD). However, there is no consistency in the fatty acid profile and metabolism associated with AD pathogenesis. This study aims to define the characteristics of fatty acid composition and metabolis...

journal_title：Neuroscience letters

authors： Bai YR,Wang YY,Meng DL,Shi ZL,Song XF,Yang ZZ,Zhang W,Yang L,Shi RL

更新日期：2020-11-01 00:00:00