Abstract：
:The fine-tuning of topographically organized projections in sensory systems is strongly influenced by electrical activity and use-dependent modifications in synaptic strength. Since calcineurin (CaN), a Ca(2+)-calmodulin dependent serine/threonine phosphatase has been associated with activity-dependent modifications in synaptic efficacy we studied the effects of systemic and local administration of CaN inhibitors during the critical period of development of the uncrossed retinocollicular projection in pigmented rats. We found that the expression of the catalytic subunit of calcineurin (CaNA) occurs throughout early development in the visual layers of the superior colliculus and peaks at PND14 when eye opening is complete. The functional blockade of CaN activity by means of a systemic treatment with cyclosporine A (CsA) during the second postnatal week, induces sprouting of uncrossed retinal axons outside their main terminal zones. Additionally, the local treatment with intracranial implants of Elvax loaded with either CsA or a cell-permeable CaN inhibitory peptide (CIP) resulted in a similar expansion of retinocollicular terminal fields. Taken together, these results suggest CaN as a key element for the development of fine tuning of retinocollicular topography.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Trindade P,Antonioli-Santos R,Teixeira AC,Lanzillotta-Mattos B,Melibeu AC,Campello-Costa P,Linden R,Serfaty CAdoi
10.1016/j.neulet.2010.09.071subject
Has Abstractpub_date
2011-01-03 00:00:00pages
47-52issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(10)01310-8journal_volume
487pub_type
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