Abstract:
:Intracellular recordings were used to examine the mechanisms underlying the 5-hydroxytryptamine (5-HT)4 receptor-mediated depolarization seen in CA1 region pyramidal cells in in vitro hippocampal brain slices. This depolarization was mimicked and occluded by administration of the membrane permeable cyclic adenosine monophosphate (cAMP) analog 8-bromo-cAMP but was unaffected by blockade of protein kinase A (PKA). These results suggest that 5-HT4 receptors signal this depolarization through a cAMP-dependent but PKA-independent mechanism. In many cell types, 5-HT elicits a depolarization via cAMP by facilitating Ih, a hyperpolarization-activated cation current. In contrast, we find no evidence for the involvement of Ih in this response. Rather, this depolarization may involve a cyclic nucleotide gated channel.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chapin EM,Haj-Dahmane S,Torres G,Andrade Rdoi
10.1016/s0304-3940(02)00113-1keywords:
subject
Has Abstractpub_date
2002-05-10 00:00:00pages
1-4issue
1eissn
0304-3940issn
1872-7972pii
S0304394002001131journal_volume
324pub_type
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