Abstract:
:Studies have demonstrated the changes of the physiological characteristics of nucleus accumbens (NAc) neurons with the postnatal development of rats. In the present study, spontaneous excitatory postsynaptic currents (sEPSCs) were recorded in the slices of NAc shell (NAcS) of adult and juvenile rats. Our results demonstrate that both the average amplitude of sEPSCs and the average frequency of sEPSCs in the NAcS slices of adult rats decreased significantly than that in juvenile rats. The average half width of sEPSCs in the NAcS slices in adult rats increased significantly than that in juvenile rats. The rise time of sEPSCs, the rise 50 time of sEPSCs and the 10-90 rise time of sEPSCs in the NAcS slices increased significantly in adult rats than that in juvenile rats. The decay time of sEPSCs in the NAcS slices also increased significantly in adult rats than that in juvenile rats. The above results strongly indicate that there are marked changes in the electrophysiological properties of single sEPSC in the NAcS slices of juvenile and adult rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Liu XD,Liu Z,Kong QY,Zhang JJ,Wang Y,Yu LCdoi
10.1016/j.neulet.2011.03.086subject
Has Abstractpub_date
2011-06-01 00:00:00pages
80-3issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(11)00410-1journal_volume
496pub_type
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