Abstract:
:The optic nerve (ON) in adult rats was transected intraorbitally followed by retrograde labelling of retinal ganglion cells (RGCs) with fluorescence dye (DiI). A two phase reduction of axotomized RGCs was represented in the retina until 15 days after ON transection. The critical period of RGC loss is around 7 days after axotomy. In this period, the capability of neurite regeneration from RGCs in culture was strongly intensified by ON transection. These findings indicate that the 7th day after axotomy is important for both RGC survival and regeneration.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Takano M,Horie Hdoi
10.1016/0304-3940(94)91096-0subject
Has Abstractpub_date
1994-07-04 00:00:00pages
129-32issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)91096-0journal_volume
175pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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