Abstract:
:The alpha1-adrenergic receptors may contribute to cognitive functions relevant to schizophrenia. Following the discovery of an association between polymorphisms in the regulatory region of the alpha1A-adrenergic receptor and schizophrenia we investigated the expression of mRNA for this receptor between schizophrenics (n=19) and controls (n=19) using a TaqMan approach in post-mortem brains. No differences were found suggesting that mRNA levels are not altered in schizophrenia. Genotypic data for the subjects found that possession of the previously associated genotypes did not convey a difference in mRNA expression suggesting that these polymorphisms do not affect the level of transcription.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Clark DA,Mancama D,Kerwin RW,Arranz MJdoi
10.1016/j.neulet.2006.03.025subject
Has Abstractpub_date
2006-07-03 00:00:00pages
248-51issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(06)00284-9journal_volume
401pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.01.011
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01426-x
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