Abstract:
:Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adults, both under resting conditions and after K depolarization. This difference was still observed after incubation with an endogenous heavy metal chelator. To avoid the calcium buffering effect of quin-2, [Ca2+]i values were determined with the use of a null-point method and with fura-2. These methods confirmed the increase in [Ca2+]i with age in synaptosomes. The increase in [Ca2+]i in nerve endings may be pathologically important in brain ageing.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Martinez A,Vitórica J,Satrústegui Jdoi
10.1016/0304-3940(88)90234-0subject
Has Abstractpub_date
1988-06-07 00:00:00pages
336-42issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(88)90234-0journal_volume
88pub_type
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