Augmentation of rat brain endogenous monoamine oxidase inhibitory activity (tribulin) by electroconvulsive shock.

Abstract:

:The effects of acute and subacute supramaximal and submaximal electroshock-induced convulsions on rat brain tribulin activity were investigated. Both supramaximal and submaximal shocks induced a marked increase, as measured 30 min after the onset of convulsions, with a significantly greater effect from the former. The effects were no longer present 24 h after stimulus. Repeated electroshock for 5 and 10 days showed that submaximal stimuli produced little change, whereas supramaximal shock brought about a significant increase in tribulin activity, the effect being greater with 10-day exposure. The results are not inconsistent with the clinical observation that a single electroconvulsive therapy (ECT) shock has little clinical usefulness but that repeated shocks, spread over several days, result in therapeutic benefit due, perhaps, to an increase in brain concentrations of tribulin, an endogenous monoamine oxidase inhibitor.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bhattacharya SK,Banerjee PK,Glover V,Sandler M

doi

10.1016/0304-3940(91)90132-d

subject

Has Abstract

pub_date

1991-04-15 00:00:00

pages

65-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(91)90132-D

journal_volume

125

pub_type

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