Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus.

Abstract:

:Bilateral complete transection of the fimbria-fornix causes a significant increase in nerve growth factor (NGF) content both in the septum and hippocampus of the adult rat as measured by a sensitive immunoassay 7 days after lesioning. The finding, that elevation of NGF in septum (250%) was much more pronounced than that in the hippocampus (30-50%), cannot be explained by retrograde axonal transport. Degeneration of central cholinergic neurons might be a potential trigger for NGF production in the CNS.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Weskamp G,Gasser UE,Dravid AR,Otten U

doi

10.1016/0304-3940(86)90449-0

subject

Has Abstract

pub_date

1986-09-25 00:00:00

pages

121-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90449-0

journal_volume

70

pub_type

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