In vivo release of enkephalin from the globus pallidus.

Abstract:

:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the perfusing medium. Local perfusion with veratrine also enhanced enkephalin release. Furthermore, in vivo, electrical stimulation of the rat caudo-putamen enhanced enkephalin release in the pallidum. This latter finding is consistent with a functional strio-pallidal enkephalin-containing pathway previously postulated by immunohistochemical or lesion experiments.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bayon A,Shoemaker WJ,Lugo L,Azad R,Ling N,Drucker-Colin RR,Bloom FE

doi

10.1016/0304-3940(81)90360-8

subject

Has Abstract

pub_date

1981-06-12 00:00:00

pages

65-70

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(81)90360-8

journal_volume

24

pub_type

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