Abstract:
:The objective of the study was to investigate the presence and distribution of nerve cell bodies and small ganglia in the stroma of human submandibular gland. A retrospective immunohistochemical study in 13 human submandibular glands, fixed in neutral buffered formalin and embedded in paraffin wax, was undertaken. Six glands were excised in the course of radical neck dissection for oral squamous cell carcinoma and were disease-free, six showed sialadenitis, and one was involved by tuberculosis. Primary antibodies applied were neuron specific enolase, synaptophysin, and glial fibrilliary acidic protein. Neuron specific enolase and synaptophysin positive nerve cell bodies and small ganglia were found in 8/13 and 13/13 glands, respectively. They were found in the interlobular connective tissue stroma of human SMG, in close association to salivary parenchymal cells and blood vessels, and some of them were incorporated in GFAP positive peripheral nerves. To our knowledge, nerve cell bodies and small ganglia have been described only in the connective tissue stroma of autotransplanted human SMG and their functional importance is not clear.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tosios KI,Nikolakis M,Prigkos AC,Diamanti S,Sklavounou Adoi
10.1016/j.neulet.2010.03.045subject
Has Abstractpub_date
2010-05-07 00:00:00pages
53-5issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00342-3journal_volume
475pub_type
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