Abstract:
:Benzodiazepine (Bzd) agonist, diazepam (Dzp) and inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM); acetylcholinesterase inhibitor, physostigmine (Physo) and muscarinic antagonist, scopolamine (Scopo), were investigated for their mnesic effect in a passive avoidance (PA) task in rats. Impairments were observed after Dzp- and/or Scopo-pretraining treatments. Physo was without effect but antagonized the Dzp-induced impairments. beta-CCM enhanced acquisition and antagonized the Scopo-induced impairing effect. All these drugs had no effect in posttraining administration.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Anglade F,Bizot JC,Dodd RH,Baudoin C,Chapouthier Gdoi
10.1016/0304-3940(94)90808-7subject
Has Abstractpub_date
1994-12-05 00:00:00pages
247-50issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90808-7journal_volume
182pub_type
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journal_title:Neuroscience letters
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