Abstract:
:Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDAT cases and was maximal in the temporal cortex. The fall in ChAT activity observed in the temporal cortex was accompanied by a significant reduction (47%) in immunoreactive somatostatin.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Rossor MN,Emson PC,Mountjoy CQ,Roth M,Iversen LLdoi
10.1016/0304-3940(80)90177-9subject
Has Abstractpub_date
1980-12-01 00:00:00pages
373-7issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(80)90177-9journal_volume
20pub_type
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