Abstract:
:Apoptosis is thought to play a role in neuronal pathology in schizophrenia. Recently, the GSN gene was reported to have anti-apoptotic properties. In a genome-wide expression analysis on schizophrenia, GSN was also found to be significantly down-regulated in schizophrenia. All the hints suggest that GSN is a novel candidate gene in occurrence of schizophrenia. In this work, we genotyped 3 SNPs around the GSN locus in 493 sets of the Han Chinese trio sample using allele-specific PCR. A weak association or a marginally positive result was detected (0.05 for P-value of the overtransmitted haplotype and 0.02 for a global P-value).
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Xi ZR,Qin W,Yang YF,He G,Gao SH,Ren MS,Peng YW,Zhang Z,He Ldoi
10.1016/j.neulet.2004.09.041keywords:
subject
Has Abstractpub_date
2004-12-06 00:00:00pages
200-3issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(04)01174-7journal_volume
372pub_type
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