Abstract:
:In brainstem slices of guinea pigs perfused with artificial cerebro-spinal fluid (ACSF), the discharge of all the spontaneously active neurons of the medial vestibular nucleus (MVN) is regular. It has been reported that prolonged exposure to a low Ca(2+) medium could induce these neurons to fire bursts of spikes. In this study, we performed a systematic exploration of the spontaneous activity of the guinea pig MVN neurons by extracellular recordings in slices perfused either with a low Ca(2+)-high Mg(2+) medium, or with ACSF added with omega-agatoxin-IVA and with omega-conotoxin-GVIA. The percentage of recorded neurons which fired bursts, was 67% in low Ca(2+)-high Mg(2+) medium and 34% under the action of Ca(2+) channel blockers. These results show that the sensitivity of the firing properties to divalent cations is not shared by all of the MVN neurons and that the regularity of firing of a class of MVN neurons depends on the Ca(2+) channels they express in their membranes.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ris L,Godaux Edoi
10.1016/s0304-3940(00)01677-3keywords:
subject
Has Abstractpub_date
2001-01-12 00:00:00pages
142-4issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(00)01677-3journal_volume
297pub_type
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