Abstract：
:The primary component of amyloid deposits found in the brains of patients with Alzheimer's disease is the beta-amyloid protein, a derivative of a much larger precursor protein (beta PP). We have previously reported that overexpression of carboxyl (COOH)-terminal fragments of beta PP from an integrated DNA construct leads to degeneration of neuronally differentiating mouse embryonic stem cells and that the neuronal degeneration is related to approximately 14- and 15-kDa COOH-terminal fragments of the precursor protein. We here demonstrate that these putative cytotoxic fragments contain intact beta-amyloid protein. When such transformed cell lines are treated with dimethyl sulfoxide to induce differentiation into muscle cells, however, the resulting muscle cells remain viable (as do control non-transformed cells), despite the production of comparable amounts of the 14- and 15-kDa fragments. These results are consistent with the hypothesis that particular COOH-terminal fragments of beta PP are amyloidogenic and neurotoxic.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fukuchi K,Sopher B,Furlong CE,Smith AC,Dang N,Martin GMdoi
10.1016/0304-3940(93)90192-nsubject
Has Abstractpub_date
1993-05-14 00:00:00pages
145-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90192-Njournal_volume
154pub_type
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