Abstract:
:The presence and micro-anatomical localization of muscarinic cholinergic receptors were assessed in dorsal root ganglia of chick embryo during development using radioligand binding and immunocytochemical techniques, respectively. The non-selective muscarinic cholinergic receptor radioligand [3H]quinuclidinyl benzilate was specifically bound to sections of chick dorsal root ganglia with a dissociation constant value (Kd) of 0.75 +/- 0.02 nM and a maximum density of binding sites (Bmax) of 7.2 +/- 0.5 fmol/mg tissue. [3H]Quinuclidinyl benzilate binding was partially sensitive to pirenzepine displacement. This suggests that muscarinic cholinergic receptors expressed by dorsal root ganglia of chick embryo at least in part belong to the M1 muscarinic receptor subtype. Immunocytochemical analysis confirmed the presence of muscarinic receptors in the ganglia. These findings suggest that neurons of dorsal root ganglia, which are known to express cholinergic markers such as choline acetyltransferase, acetylcholinesterase and high affinity choline uptake, are also cholinoceptive.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tata AM,Biagioni S,Ricci A,Amenta F,Augusti-Tocco Gdoi
10.1016/0304-3940(95)11474-bsubject
Has Abstractpub_date
1995-04-21 00:00:00pages
139-42issue
3eissn
0304-3940issn
1872-7972pii
030439409511474Bjournal_volume
189pub_type
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journal_title:Neuroscience letters
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