Abstract：
:Thyrotropin-releasing hormone (TRH) metabolism in NIH:N mouse cerebral cortex and spinal cord was studied with high pressure liquid chromatography. Degradation of added TRH was significantly (P less than 0.001) slower in the spinal cord (2.19 +/- 0.46%/min) than in the cerebral cortex (7.54 +/- 0.31%/min). Bacitracin, a non-competitive inhibitor of TRH deamidase, inhibited TRH degradation by 61.3 +/- 3.7% in the spinal cord but only by 35.9 +/- 1.0% in the cerebral cortex (P less than 0.001). Catabolism of TRH in the mouse spinal cord proceeds at a slower rate and predominantly via the TRH deamidase pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schwartz TM,Turner JG,Brooks BRdoi
10.1016/0304-3940(86)90560-4subject
Has Abstractpub_date
1986-11-11 00:00:00pages
209-12issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90560-4journal_volume
71pub_type
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