Neurite outgrowth of murine cerebellar granule cells can be enhanced by aniracetam with or without alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA).

abstract：:Limited work has been done to investigate the molecular mechanisms behind the process of demyelination and remyelination that occurs in response to chronic nerve compression (CNC) injury. In the present study, we investigated the expression of the transcription factors krox-20 and c-jun, positive and negative regulato...

journal_title：Neuroscience letters

authors： Pham K,Nassiri N,Gupta R

更新日期：2009-11-13 00:00:00

abstract：:We evaluated the modulation of baroreceptor reflex (BRR) response by locus coeruleus (LC) in adult, male Sprague-Dawley rats anesthetized with urethane (1.5 g/kg, i.p.). Under an electrical stimulation condition that did not appreciably alter the basal systemic arterial pressure and heart rate, the LC significantly su...

journal_title：Neuroscience letters

authors： Chan JY,Jang SF,Chan SH

更新日期：1992-09-14 00:00:00

abstract：:A well-known event-related potential (ERP) component-the recognition potential (RP) is a response to recognizable stimuli, peaking at around 200-250 ms. The aim of the present study is to put to the test the contrasting perceptual and semantic accounts of the RP, with manipulation of word meaning and presentation form...

journal_title：Neuroscience letters

authors： Zhang Y,Liu Q,Zhang Q

更新日期：2009-04-17 00:00:00

abstract：:The effect of chlorpromazine (CPZ) on deactivation of N-methyl-D-aspartate (NMDA)-induced currents was studied in the whole-cell configuration of the patch-clamp technique in cultured rat hippocampal neurons. We report that CPZ (at 30-1000 microM) strongly slowed down the deactivation process in a dose-dependent manne...

journal_title：Neuroscience letters

authors： Zarnowska ED,Mozrzymas JW

更新日期：2001-11-23 00:00:00

abstract：:Lesch-Nyhan syndrome (LNS), caused by the complete deficiency of hypoxanthine phosphoribosyltransferase (HPRT), is characterized by a neurological deficit, the etiology of which is still unclear. Evidence has accumulated indicating that it reflects dopamine deficiency associated with defective arborization of dopamine...

journal_title：Neuroscience letters

authors： Boer P,Brosh S,Wasserman L,Hammel I,Zoref-Shani E,Sperling O

更新日期：2001-04-27 00:00:00

abstract：:Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists. The Fmr1 knockout (KO) mouse has been found to be a ...

journal_title：Neuroscience letters

authors： Wrenn CC,Heitzer AM,Roth AK,Nawrocki L,Valdovinos MG

更新日期：2015-01-12 00:00:00

abstract：:Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle that is FDA-approved as an intravenous iron replacement therapy for the treatment of iron deficiency anemia in patients with chronic kidney disease. Ferumoxytol has also been used as a contrast agent for cerebral blood volume mapping by mag...

journal_title：Neuroscience letters

authors： Doyle KP,Quach LN,Arceuil HE,Buckwalter MS

更新日期：2015-01-01 00:00:00

abstract：:We have conjectured that axons embody a post transcriptional sprouting programme repressed by mature Schwann cells. Injured nerves of Wld(s) mice neither degenerate nor regenerate for several weeks but axons do regrow if the resident cells of the distal stump are destroyed. To test our hypothesis we made an extended c...

journal_title：Neuroscience letters

authors： Iñiguez A,Alvarez J

更新日期：1999-06-18 00:00:00

abstract：:The febrile responses induced by i.v. administrations of staphylococcal enterotoxin A (SEA) was mimicked by direct injection of SEA into the organum vasculosum laminae terminalis (OVLT) in unanesthetized rabbits. Compared with the febrile responses induced by i.v. injection of SEA, the OVLT route of injection required...

journal_title：Neuroscience letters

authors： Huang WT,Lin MT,Won SJ

更新日期：1997-10-24 00:00:00

abstract：:Dissociable circadian rhythms of sleep and body temperature in primates are thought to be regulated by independent oscillators whereas the uncoupling of circadian rhythms has not been well described in other mammals. Therefore, we made simultaneous recordings of non-rapid-eye-movement-sleep (NREMS), rapid-eye-movement...

journal_title：Neuroscience letters

authors： Ikeda M,Sagara M,Inoué S

更新日期：2000-02-04 00:00:00

abstract：:Discrete brain structures were analysed for gamma-aminobutyric acid (GABA) and vasopressin content in normo- and hypotensive rats treated with the glutamic acid decarboxylase inhibitor, 3-mercaptopropionic acid (MPA) and the GABAA agonist muscimol. In the normotensive group treated with MPA only, the concentration of ...

journal_title：Neuroscience letters

authors： Magnusson A,Höglund U,Sjöquist M

更新日期：1989-07-03 00:00:00

abstract：:Glutamatergic system, the main stimulating system of the brain, plays an important role in the pathogenesis of schizophrenia. Hippocampus, a structure crucial for memory and cognitive functions and rich in glutamatergic neurons, is a natural object of interest in studies on psychoses. Sarcosine, a glycine transporter ...

journal_title：Neuroscience letters

authors： Strzelecki D,Podgórski M,Kałużyńska O,Gawlik-Kotelnicka O,Stefańczyk L,Kotlicka-Antczak M,Gmitrowicz A,Grzelak P

更新日期：2015-10-08 00:00:00

abstract：:This study aimed to determine the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on electroencephalograms (EEGs) of rats. Fifteen Sprague-Dawley rats were subject to 100 pulses of 0.5 Hz rTMS, or sham stimulation. EEGs were recorded before stimulation and within 1 min after rTMS or sham st...

journal_title：Neuroscience letters

authors： Li L,Yin Z,Huo X

更新日期：2007-01-29 00:00:00

abstract：:Dopamine-derived 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, released an enormous amount of serotonin in the rat striatum; the concentration of serotonin increased from undetectable level to 2.53 +/- 0.12 and 3.69 +/- 0.01 microM after perfusion of (R)- and (S)salsolinol, respective...

journal_title：Neuroscience letters

authors： Maruyama W,Nakahara D,Dostert P,Hashiguchi H,Ohta S,Hirobe M,Takahashi A,Nagatsu T,Naoi M

更新日期：1993-01-12 00:00:00

abstract：:To investigate the role of Cl(-)-stimulated Mg(2+)-ATPase (Cl(-)-ATPase) in neurons, we examined the effects of ethacrynic acid (0.3 mM), which completely inhibits Cl(-)-ATPase on the intracellular Cl- concentrations of cultured rat hippocampal neurons, using Cl(-)-sensitive fluorescent probes. Ethacrynic acid and ATP...

journal_title：Neuroscience letters

authors： Inoue M,Hara M,Zeng XT,Hirose T,Ohnishi S,Yasukura T,Uriu T,Omori K,Minato A,Inagaki C

更新日期：1991-12-16 00:00:00

abstract：:Damage to sub-cortical white matter is a key substrate of vascular dementia (VaD) leading to deficits in executive function and cognitive processing speed. Dynamin1 is a 100 kDa protein, accounting for 0.4% of the total brain protein, and has a central role in many intracellular processes such as synaptic vesicle traf...

journal_title：Neuroscience letters

authors： Mulugeta E,Vallortigara J,Francis PT,Hye A,Kalaria RN,Perry EK,Lovestone S,Ballard CG

更新日期：2014-03-20 00:00:00

abstract：:Morphological changes induced by 30 min of hypoxia (incubation in medium saturated with 95% N2-5% CO2 instead of the normal 95% O2-5% CO2) were investigated in neurons (layers II/III of the parietal cortex) of rat neocortical brain slices. The cells were identified as intact, reversibly or irreversibly injured. As exp...

journal_title：Neuroscience letters

authors： Garcia de Arriba S,Franke H,Pissarek M,Nieber K,Illes P

更新日期：1999-09-24 00:00:00

abstract：:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhib...

journal_title：Neuroscience letters

authors： Jolkkonen J,Jenner P,Marsden CD

更新日期：1994-10-24 00:00:00

abstract：:Following focal brain lesions, complex adaptive processes take place in remote intact areas. The present study examines changes in NMDA (N-methyl-D-aspartate), AMPA ((+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate receptors following focal photothrombotic ischemic lesions using quantitative...

journal_title：Neuroscience letters

authors： Que M,Schiene K,Witte OW,Zilles K

更新日期：1999-10-01 00:00:00

abstract：:Novel retinal pigment epithelial cell gene (Norpeg, Rai14), a developmentally regulated mouse gene, encodes a protein containing six ankyrin repeats and a coiled-coil domain. The objective of the present study was to characterize the Norpeg protein and to analyze its expression in mouse retina using an antibody prepar...

journal_title：Neuroscience letters

authors： Kutty RK,Samuel W,Chen S,Vijayasarathy C,Dun Y,Mysona B,Wiggert B,Smith SB

更新日期：2006-09-01 00:00:00

abstract：:The present study was aimed at differentiate, within the parietal cortex, the areas underlying visuospatial working memory/attentionnal processes and those devoted to arithmetic processing. We compared, using positron emission tomography, the cerebral networks activated in two groups of subjects, one solving two-by-tw...

journal_title：Neuroscience letters

authors： Zago L,Tzourio-Mazoyer N

更新日期：2002-10-04 00:00:00

abstract：:To determine how target-derived nerve growth factor (NGF) affects sensory neuronal survival and the development of topographic nerve projections in the spinal cord, anatomical studies were performed on transgenic mice that overexpress NGF in skin and other keratinized epithelial structures. Transgenic animals showed a...

journal_title：Neuroscience letters

authors： Mendelson B,Albers KM,Goodness TP,Davis BM

更新日期：1996-06-14 00:00:00

abstract：:The expression of five muscarinic receptor mRNAs (m1, m2, m3, m4, m5) was examined in neostriatum, hippocampus and frontal cortex of 3, 18, and 33 month old rats. Transcripts for ml (3.0 kb), m2 (6.2 kb), m3 (4.5 kb) and m4 (3.3 kb) were detected in all brain regions studied. A 6.0 kb transcript for the m5 muscarinic ...

journal_title：Neuroscience letters

authors： Lee HJ,Clagett-Dame M,Heideman W,Weiler MS

更新日期：1994-06-20 00:00:00

abstract：:Peripheral nerve transection results in a disconnection of the neuron from its target. As a result, a series of metabolic changes occur in the cell body that may cause neuronal death, mainly by apoptotic mechanisms. Although neurons from neonatal animals are the most susceptible, peripheral, lesion-induced, neuronal l...

journal_title：Neuroscience letters

authors： Pierucci A,de Oliveira AL

更新日期：2006-03-27 00:00:00

abstract：:Several side activities have been attributed to butyrylcholinesterase (BChE), including aryl acylamidase (AAA) activity, which is an amidase-like activity with unknown physiological function splitting the artificial substrate o-nitroacetanilide. For avians, extensive developmental data have pointed to neurogenetic fun...

journal_title：Neuroscience letters

authors： Weitnauer E,Robitzki A,Layer PG

更新日期：1998-10-02 00:00:00

abstract：:For several neurodegenerative disorders, including Parkinson's Disease (PD) and Alzheimer's Disease (AD), microRNAs (miRNAs) have been known to play a crucial role. So, in this study miR-132 and its role in PD cell models was investigated. We wanted to investigate the survival or death pathway involved in PD. We obser...

journal_title：Neuroscience letters

authors： Qazi TJ,Lu J,Duru L,Zhao J,Qing H

更新日期：2021-01-01 00:00:00

abstract：:Thin bundles dissected from mouse soleus muscles were kept in culture media containing 10% calf serum. After 3 days of culture at 37 degrees C the muscles were tested for acetylcholine (ACh) sensitivity by measuring the force of the contracture produced by 10 microM ACh. The ACh-receptor density was measured by the [1...

journal_title：Neuroscience letters

authors： Lorković H,Feyrer A

更新日期：1984-10-26 00:00:00

abstract：:Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits...

journal_title：Neuroscience letters

authors： Kim WR,Sun W

更新日期：2013-08-26 00:00:00

abstract：:Estrogen was shown to promote neuronal survival against several neurotoxic insults including β-amyloid (Aβ). The proposed mechanism includes the activation of the mitogen activated protein kinase/extracellular signal-regulated kinase (Mapk/Erk), phosphatidylinositol 3-kinase/Akt pathways and the upregulation of antiap...

journal_title：Neuroscience letters

authors： Mateos L,Persson T,Katoozi S,Gil-Bea FJ,Cedazo-Minguez A

更新日期：2012-01-11 00:00:00

abstract：:Infection of the snail Lymnaea stagnalis with the schistosome parasite Trichobilharzia ocellata results in inhibition of reproduction and in giant growth. Parasite-related effects on the neuroendocrine centres that control these processes were studied electrophysiologically. Haemolymph from infected snails reduced the...

journal_title：Neuroscience letters

authors： Hordijk PL,de Jong-Brink M,ter Maat A,Pieneman AW,Lodder JC,Kits KS

更新日期：1992-03-02 00:00:00