Abstract:
:Activin A levels are elevated in the cerebrospinal fluid (CSF) of patients with meningitis and in the sera of patients with sepsis. The source(s) of the elevated concentrations of activin A in CSF and serum have not yet been discovered. Here we demonstrate that primary mouse microglial cells and peritoneal macrophages release activin A after treatment with agonists of Toll-like receptor (TLR) 2, 4, and 9. These findings provide further evidence for a role of activin in the innate immune response and suggest that microglial cells and macrophages are a source of elevated activin A concentrations observed in the CSF during bacterial meningitis and in the systemic circulation during sepsis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ebert S,Zeretzke M,Nau R,Michel Udoi
10.1016/j.neulet.2006.11.065subject
Has Abstractpub_date
2007-02-21 00:00:00pages
241-4issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(06)01291-2journal_volume
413pub_type
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