Abstract:
:gamma-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mammalian central nervous system (CNS) and an understanding of the development of receptors for this compound is of considerable interest. In this study, 3 monoclonal antibodies directed against the GABAA/benzodiazepine (GABA/BDZ) receptor were utilized in immunocytochemical experiments to localize receptor sites on neurons in dissociated cultures from fetal rat hypothalamus. Immunoreactivity was restricted to distinct patches on the plasma membrane of neurons. Analogous patches were observed on the surface of type 1 astrocytes, but not on type 2 astrocytes or oligodendrocytes. In membrane extracts from whole brain these antibodies reacted with two proteins (50 and 55 kDa) whereas extracts of cultured astrocytes yielded a single protein of approximately 63 kDa. Thus the identity of the glial protein remains unclear, but this study provides evidence for the presence of shared epitopes of the GABA/BDZ-receptor on both neurons and glia, and suggests that the astrocytic receptors may be important to nervous system function. Moreover it indicates that in vitro GABA/BDZ-receptors may form aggregates which would account for the restricted patterns of GABA sensitivity reported in some electrophysiological studies.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ventimiglia R,Grierson JP,Gallombardo P,Sweetnam PM,Tallman JF,Geller HMdoi
10.1016/0304-3940(90)90443-dsubject
Has Abstractpub_date
1990-07-31 00:00:00pages
131-6issue
2-3eissn
0304-3940issn
1872-7972pii
0304-3940(90)90443-Djournal_volume
115pub_type
杂志文章abstract::Numerous studies have demonstrated that learning and memory abilities in the course of normal aging cognitive abilities tend to decline and Nrf2 expression appears to decline with aging. So, Nrf2 pathway has been identified as a promising therapeutic target for neurodegenerative diseases. The organosulfur compounds, a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.02.054
更新日期:2012-04-11 00:00:00
abstract::In anesthetized cats selective activation of fine muscle afferents of the hindlimb by KCl or bradykinin (Brad.) induced reflex changes in the urinary bladder. The nature of the reflex responses depended on the functional state of the bladder: they were excitatory when the bladder was quiescent and inhibitory during la...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(79)90048-x
更新日期:1979-01-01 00:00:00
abstract::A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes. Complement activation is one of the cardinal pathological features of the inflammation. Intensive AD association studies investigating polymorphisms in inflammatory-related genes have been recently perfor...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3940(02)01218-1
更新日期:2003-01-16 00:00:00
abstract::Accumulating evidences have pointed out that neuroinflammation is involved in Parkinson's disease (PD) pathogenesis. Toll-like receptor 3 (TLR3), as a member of pattern-recognition receptors (PRRs), is known to play a pivotal role in inflammatory responses and immune responses. It was recently suggested that TLR3 was ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135005
更新日期:2020-05-29 00:00:00
abstract::Disturbed motor control of the fingers, as revealed by the response to unexpected loading of an object held in a precision grip, or to finger perturbation during isometric holding, has been studied in patients with Huntington's disease (HD) and in normal subjects. In normal subjects unexpected loading elicited a refle...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00264-4
更新日期:1997-04-25 00:00:00
abstract::Carbonic anhydrase (CA) activity was localized histochemically in the retina and brain of the honeybee drone. A positive reaction that could be inhibited with 10(-5) M acetazolamide was found only in brain glial cells such as those in the lamina and medulla of the optic lobes. In the retina, neither the photoreceptors...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90426-0
更新日期:1988-02-15 00:00:00
abstract::Morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. These sites included the dorsal central gray area (DCG), the ventral reticular formation (VRF) and the lateral tegmentum (LT). Naloxone, which had no effect alone, blocked the morphine effects of all three av...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(78)90035-6
更新日期:1978-11-01 00:00:00
abstract::Tourette syndrome/chronic tic phenotype (TS-CTD) is a neurological disorder manifested particularly by motor and vocal tics and associated with a variety of behavioral abnormalities. Recently, the mitochondrial ribosomal protein L3 gene (MRPL3) S75N, the DnaJ (Hsp40) homolog subfamily C member 13 gene (DNAJC13) A2057S...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.03.097
更新日期:2012-05-23 00:00:00
abstract::The effect of chronic alcoholism in the neuronal nuclear area (karyometry) of the lateral entorhinal cortex at three rostro-caudal levels (rostral, intermediate and caudal) has been studied in 19 alcoholic subjects and in 15 aged-matched controls. Cases were distributed into three groups according to their age (29-44,...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)11117-2
更新日期:1995-01-02 00:00:00
abstract::Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, has been developed as a drug to be used for treatment of stroke for hundreds of years. However, the underlying mechanisms remain unknown. In the present study, the effects of BYHWD on delayed neuronal death of hippocampus after transient forebrain ischem...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00522-6
更新日期:2003-07-31 00:00:00
abstract::We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90475-8
更新日期:1989-08-14 00:00:00
abstract::Five min bilateral carotid artery occlusion (BCO) in gerbils results in selective degeneration of neurons in the hippocampus, striatum and cortex, and an increase in spontaneous locomotor activity. These phenomena were examined to determine if an association could be made between the site or degree of neuronal degener...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90762-i
更新日期:1991-07-08 00:00:00
abstract::Morphine and other opioids have direct analgesic actions in the spinal cord and chronic spinal administration of opioid agonists is used clinically in patients suffering from severe, chronic pain. Neuropathic pain resulting from peripheral nerve injury is often less sensitive to opioid therapy than other forms of chro...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.12.067
更新日期:2004-05-06 00:00:00
abstract:INTRODUCTION:The saccadic paradigm has been used to investigate specific cortical networks involving attention. The behavioral and electrophysiological investigations of the SEM contribute significantly to the understanding of attentive patterns presented of neurological and psychiatric disorders and sports performance...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.06.066
更新日期:2012-08-15 00:00:00
abstract::NGP1-01, a member of the pentacycloundecylamine cage compound family, was recently shown to exhibit both NMDA receptor channel blocking and L-type calcium channel antagonism activity. In the present study, focal ischemia was induced in mice by permanent middle cerebral artery occlusion (MCAO) to test for potential neu...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.03.042
更新日期:2005-07-22 00:00:00
abstract::Primary neuron cultures are widely used in research due to the ease and usefulness of observing individual cells. Therefore, it is vital to understand how variations in culture conditions may affect neuron physiology. One potential variation for cultured neurons is a change in intracellular transport. As transport is ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.06.026
更新日期:2008-08-22 00:00:00
abstract::The effects of aging on the stress response of the septo-hippocampal cholinergic neurons was assessed by monitoring hippocampal acetylcholine (ACh) release. Young (3-4 month old) and aged (23-24 month old) male rats were subjected to restraint stress for 1 h. ACh was elevated within 15 min of the onset of restraint st...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13340-7
更新日期:1997-01-24 00:00:00
abstract::The purpose of this study was to determine whether the loss of protein kinase C (PKC) from adrenal chromaffin cells affected the enhancement of high K(+)- and forskolin-stimulated tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2) activity observed in cells treated with insulin-like growth factor-I (IGF-I)....
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)12144-7
更新日期:1995-12-08 00:00:00
abstract::Adenosine has been implicated in the regulation of rapid eye movement sleep (REMS). In an attempt to understand the mechanism of production of adenosine in relation to REMS it was hypothesized that should it be involved in REMS, the latter's deprivation is likely to affect its synthetic machinery. Hence, male albino r...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)12453-8
更新日期:1996-03-15 00:00:00
abstract::Oleamide is a recently described lipid, obtained from the cerebrospinal fluid of sleep-deprived cats. It has been observed that oleamide possesses several biological effects, such as sleep induction, and immunological suppression as well as serotonin and gamma-aminobutyric acid receptors activation. In addition, oleam...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02256-x
更新日期:2001-11-02 00:00:00
abstract::Previous in vivo studies have indicated that both arginine vasopressin (AVP) and angiotensin II (ANG II) can modulate the baroreflex by acting on the area postrema (AP). In the present study, effects of AVP and ANG II on AP neuronal activity were investigated by recording extracellular activity in a rabbit brainstem s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11520-7
更新日期:1995-05-05 00:00:00
abstract::Binding of [3H]ethynylbicycloorthobenzoate ([3H]EBOB) to the gamma-aminobutyric acid type A (GABAA) receptor of cultured cerebellar granule neurons is inhibited by GABA, muscimol and 3-aminopropanesulfonic acid with IC50 values of 69-250 nM. Sensitivity to these GABA mimetics is lower by 3-4-fold for cerebellum and 10...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00206-1
更新日期:1997-04-04 00:00:00
abstract::MicroRNAs (miRs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by mediating mRNA degradation or transcriptional inhibition. MiRs were implicated in the pathogenesis of numerous neurodegenerative diseases, including Parkinson's disease (PD). In this study we analyzed the poss...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.08.001
更新日期:2013-10-11 00:00:00
abstract::The pigment of human substantia nigra, neuromelanin, has been thought to be derived from dopamine. To examine the genesis of neuromelanin, we advanced a new hypothesis that neuromelanin is formed by oxidation of dopamine and cysteinyldopamine. On the basis of this hypothesis, synthetic neuromelanins were obtained by t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90336-r
更新日期:1991-09-30 00:00:00
abstract::Nitric oxide (NO) is an important messenger in the central nervous system to mediate male copulatory behavior. EGb 761, a standardized extract of Gingko biloba, has been reported to facilitate male copulation in rats. The present study is to determine the effects of neuronal nitric oxide synthase (nNOS) in the medial ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.06.028
更新日期:2011-08-18 00:00:00
abstract::Hypoxia is one of the important physiological stimuli that are often associated with a variety of pathological states such as ischemia, respiratory diseases, and tumorigenesis. In the central nervous system, hypoxia that is accompanied by cerebral ischemia not only causes neuronal cell injury, but may also induce path...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.05.038
更新日期:2004-08-12 00:00:00
abstract::Peripheral inflammation induced by intraperitoneal (i.p.) injection of Lipopolysaccharide (LPS) is known to cause functional impairments in the brain affecting memory and learning. One of mechanisms may be the interference with neurotrophin (NT) expression and function. In the current study we administered a single, h...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.09.067
更新日期:2007-12-11 00:00:00
abstract::We examined by immunohistochemistry the effect of salt loading on the expression of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH) in Purkinje cells of the mouse cerebellum. In control mice, only a few Purkinje cells were positive for TH or AADC. No Purkinje cells...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11716-a
更新日期:1995-07-14 00:00:00
abstract::The discharge of 38 tibialis anterior (TA) muscle spindle endings was recorded at rest and during isometric voluntary contraction of the ankle joint in eight healthy human subjects. With the ankle joint in 110 degrees plantarflexion, 24 endings (61%) were tonically active in the resting subject. During weak voluntary ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90337-9
更新日期:1994-04-11 00:00:00
abstract::The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an ...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0304-3940(98)00423-6
更新日期:1998-06-19 00:00:00